Ruijia Zhou
Researcher in the orthopedics department of Tongji Hospital, Wuhan, and first author of a 2026 study on corilagin, a plant polyphenol that protected mouse cartilage by restoring autophagy
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (at the time of the study, 2026)
Ruijia Zhou's 2026 study, with Hongbo You as senior author, looked for a way to protect cartilage in osteoarthritis. Cartilage cells, called chondrocytes, need autophagy to clear damaged parts, and too much PI3K/AKT/mTOR signalling holds autophagy back. Inflammation driven by NF-kappaB adds to the damage.
Corilagin, a polyphenol from several medicinal plants, damped both PI3K/AKT/mTOR and NF-kappaB in chondrocytes. Autophagy recovered and the cells produced more extracellular matrix, the tough material of cartilage. In mice whose knee joints were destabilised surgically (the DMM model), corilagin reduced cartilage erosion and joint damage scores. The results come from cells and mice only.
PubMed lists Ruijia Zhou at the Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. Because the name is common, no wider publication record is attributed here.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Corilagin attenuates osteoarthritis progression by coordinating NF-κB inhibition with PI3K/AKT/mTOR-associated autophagy restoration. ZHOU2026B First author: showed that corilagin restores chondrocyte autophagy and matrix synthesis via PI3K/AKT/mTOR and NF-kappaB inhibition and reduces cartilage erosion in mice. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Ruijia Zhou.
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- Hongbo You Orthopedic researcher at Tongji Hospital, Wuhan, and senior author of a 2026 mouse study showing that the plant compound corilagin slows osteoarthritis by restoring cartilage-cell autophagy
- Sheng Chen Orthopaedic researcher who contributed to a study showing that the plant compound corilagin protects joint cartilage by calming inflammation and restoring autophagy
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