NF-κB

Pathway/Complex · 3 studies in the Atlas

Master pro-inflammatory transcription factor complex that cross-talks extensively with PI3K/AKT/mTOR signalling.

The cell's main inflammation switch: a protein complex that, once released, moves into the nucleus and turns on hundreds of immune genes. It talks back and forth constantly with the PI3K/AKT/mTOR growth pathway.

Master pro-inflammatory transcription factor complex that cross-talks extensively with PI3K/AKT/mTOR signalling.

TL;DR. NF-κB appears in 3 curated studies in Oliver's mTOR Atlas: 2 in animal models; 1 at the molecular level (cells, biochemistry, structure). No study in people is recorded for it in the Atlas yet.

Evidence at a glance

Evidence	What it means	Studies
A	Animal model	2
M	Molecular — cells, biochemistry, structure	1

No direct human evidence in the Atlas for this entity yet — everything below rests on animal or molecular work.

Studies

Year	Evidence	Study
2026	A	Corilagin attenuates osteoarthritis progression by coordinating NF-κB inhibition with PI3K/AKT/mTOR-associated autophagy restoration. ZHOU2026B Corilagin restores chondrocyte autophagic flux and ECM synthesis by inhibiting PI3K/AKT/mTOR and NF-κB signalling, reducing cartilage erosion and OARSI scores in the mouse DMM osteoarthritis model.
2018	A	Rapamycin improves healthspan but not inflammaging in nfκb1(-/-) mice. COR2018 Separates two effects of rapamycin that are usually assumed to travel together. In mice with genetically enhanced NF-kB activity, rapamycin showed no benefit in lifespan and no reduction of inflammaging, yet still reduced frailty and improved long-term memory, neuromuscular coordination and tissue architecture, with lower markers of cellular senescence. Healthspan benefit is therefore uncoupled here from suppression of inflammation, which is a boundary condition on the common claim that rapamycin acts on ageing mainly by damping inflammation. Note the mixed result: the healthspan outcomes are positive, the lifespan and inflammaging outcomes are null.
2008	M	The TSC-mTOR signaling pathway regulates the innate inflammatory response WEI2008 The TSC-mTOR pathway controls the innate inflammatory response of monocytes/macrophages.

Related entities

mTOR 2 TSC1/TSC2 1 Rapamycin 1 Age-related pathology 1CorilaginMacrophage polarization 1 Immune function 1 Akt/PKB 1 Cellular senescence 1 PI3K 1 Autophagy 1Osteoarthritis

Cite this page

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Barton, O. (2026). NF-κB [Entity page]. In Oliver's mTOR Atlas [Data set]. https://mtor-atlas.org/complex/nf-b/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_complex_nf_b,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}: NF-κB},
  howpublished = {Entity page in a data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/complex/nf-b/},
  doi          = {10.5281/zenodo.22059963}
}

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