The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

Since the discovery that rapamycin, a small molecule inhibitor of the protein kinase mTOR (mechanistic target of rapamycin), can extend the lifespan of model organisms including mice, interest in understanding the physiological role and molecular targets of this pathway has surged. While mTOR was already well known as a regulator of growth and protein translation, it is now clear that mTOR functions as a central coordinator of organismal metabolism in response to both environmental and hormonal signals.

Read the full abstract on PubMed →

Kennedy, B. K., & Lamming, D. W. (2016). The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging. Cell Metabolism. https://doi.org/10.1016/j.cmet.2016.05.009

@article{KEN2016,
  author       = {Kennedy, B. K. and Lamming, D. W.},
  title        = {{The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging}},
  journal      = {Cell Metabolism},
  year         = {2016},
  doi          = {10.1016/j.cmet.2016.05.009},
  note         = {PMID: 27304501},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record KEN2016) [Data set]. https://mtor-atlas.org/study/KEN2016/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_KEN2016,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record KEN2016},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/KEN2016/},
  doi          = {10.5281/zenodo.22059963}
}