Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate.

Lelegren M, Liu Y, Ross C, Tardif S, Salmon AB · 2016 · Pathobiology of Aging & Age-related Diseases · Atlas ID LEL2016

What this study shows

In liver and skeletal muscle from rapamycin-treated marmosets (the earlier pilot cohort), rapamycin was associated with higher expression of PSMB5, a core 20S proteasome subunit, in both tissues but not of PSMB8; proteasome activity itself did not change. Mitochondria-targeted chaperones rose in skeletal muscle but not liver, and autophagy rose in skeletal muscle and adipose tissue but not liver. The authors conclude that only some components of the proteostasis network were upregulated, and in a tissue-specific way. Boundary: tissue samples from a small pilot cohort; the changes are expression-level associations and are not shown to cause any health or lifespan effect.

Abstract

ShowHide

Inhibition of mechanistic target of rapamycin (mTOR) has emerged as a viable means to lengthen lifespan and healthspan in mice, although it is still unclear whether these benefits will extend to other mammalian species. We previously reported results from a pilot experiment wherein common marmosets (Callithrix jacchus) were treated orally with rapamycin to reduce mTOR signaling in vivo in line with previous reports in mice and humans. Further, long-term treatment did not significantly alter body weight, daily activity, blood lipid concentrations, or glucose metabolism in this cohort.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Common marmoset (Callithrix jacchus), oral rapamycin, liver, skeletal muscle and adipose tissue from a pilot cohort); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Common marmoset (Callithrix jacchus), oral rapamycin, liver, skeletal muscle and adipose tissue from a pilot cohort
Journal	Pathobiology of Aging & Age-related Diseases
Year	2016
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.3402/pba.v6.31793 · PMID 27341957 · Free full text (PMC4920937)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Oral rapamycin (pilot cohort)
Target	Proteostasis network: proteasome (PSMB5), mitochondrial chaperones, autophagy
Model	Common marmoset (Callithrix jacchus)
Effect	Tissue-specific: higher PSMB5 and mitochondrial chaperones in muscle, higher autophagy in muscle and adipose, no change in proteasome activity or in liver autophagy

In the Atlas

Cite this paper

ShowHide

Lelegren, M., Liu, Y., Ross, C., Tardif, S., & Salmon, A. B. (2016). Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate. Pathobiology of Aging & Age-related Diseases. https://doi.org/10.3402/pba.v6.31793

@article{LEL2016,
  author       = {Lelegren, M. and Liu, Y. and Ross, C. and Tardif, S. and Salmon, A. B.},
  title        = {{Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate}},
  journal      = {Pathobiology of Aging & Age-related Diseases},
  year         = {2016},
  doi          = {10.3402/pba.v6.31793},
  note         = {PMID: 27341957},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record LEL2016) [Data set]. https://mtor-atlas.org/study/LEL2016/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LEL2016,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LEL2016},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LEL2016/},
  doi          = {10.5281/zenodo.22059963}
}

Was this page useful?