mTOR: from growth signal integration to cancer, diabetes and ageing

In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein kinase to simultaneously sense energy, nutrients and stress and, in metazoans, growth factors. Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt.

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Zoncu, R., et al. (2010). mTOR: from growth signal integration to cancer, diabetes and ageing. Nature reviews. Molecular cell biology. https://doi.org/10.1038/nrm3025

@article{ZON2010,
  author       = {Zoncu, R. and Sabatini, D. M. and others},
  title        = {{mTOR: from growth signal integration to cancer, diabetes and ageing}},
  journal      = {Nature reviews. Molecular cell biology},
  year         = {2010},
  doi          = {10.1038/nrm3025},
  note         = {PMID: 21157483},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record ZON2010) [Data set]. https://mtor-atlas.org/study/ZON2010/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ZON2010,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ZON2010},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ZON2010/},
  doi          = {10.5281/zenodo.22059963}
}