mTOR: from growth signal integration to cancer, diabetes and ageing

Zoncu R, Efeyan A, Sabatini DM · 2010 · Nature reviews. Molecular cell biology · Atlas ID ZON2010

What this study shows

Authoritative review of mTOR from growth-signal integration to disease.

Abstract

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In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein kinase to simultaneously sense energy, nutrients and stress and, in metazoans, growth factors. Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Nature reviews. Molecular cell biology
Year	2010
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/nrm3025 · PMID 21157483 · Free full text (PMC3390257)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	mTORC1 / mTORC2
Model	Review
Effect	Reviews TOR signaling from growth-signal integration to cancer, diabetes and ageing

In the Atlas

Cite this paper

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Zoncu, R., Efeyan, A., & Sabatini, D. M. (2010). mTOR: from growth signal integration to cancer, diabetes and ageing. Nature reviews. Molecular cell biology. https://doi.org/10.1038/nrm3025

@article{ZON2010,
  author       = {Zoncu, R. and Efeyan, A. and Sabatini, D. M.},
  title        = {{mTOR: from growth signal integration to cancer, diabetes and ageing}},
  journal      = {Nature reviews. Molecular cell biology},
  year         = {2010},
  doi          = {10.1038/nrm3025},
  note         = {PMID: 21157483},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record ZON2010) [Data set]. https://mtor-atlas.org/study/ZON2010/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ZON2010,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ZON2010},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ZON2010/},
  doi          = {10.5281/zenodo.22059963}
}

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