TAX1BP1

Gene/Protein · 1 studies in the Atlas · also known as Tax1-binding protein 1, T6BP

Tax1-binding protein 1, an autophagy adaptor. In ESP2026 it is the link between the v-ATPase and the kinases TBK1 and ULK1: lysosomal stress sensed through the v-ATPase recruits TBK1/ULK1 to lysosomes via TAX1BP1.

A connector that brings kinases to stressed lysosomes. A connector protein that brings the kinases TBK1 and ULK1 to stressed lysosomes.

ESP2026: v-ATPase-driven recruitment of TBK1/ULK1 to lysosomes runs through TAX1BP1; recurrent ATP6V1B2 mutations in follicular lymphoma keep the route on. How the pump engages TAX1BP1 is not resolved in the abstract.

TL;DR. TAX1BP1 appears in 1 curated study in Oliver's mTOR Atlas: 1 at the molecular level (cells, biochemistry, structure). No study in people is recorded for it in the Atlas yet. It has 3 interactions in the curated pathway model.

In the pathway model

3 interactions in the curated mTOR pathway model (2 acting from TAX1BP1, 1 acting on it). Each row is a claim with the evidence behind it; the evidence code is the kind of study, not its quality.

Interaction	Mechanism	Evidence	Studies
TAX1BP1 recruits TBK1 mechanism: recruitment · this link in full · on the map table	TAX1BP1 brings the kinase TBK1 to the lysosome.TAX1BP1 acts as the adaptor that brings TBK1 onto stressed lysosomes, putting the kinase next to its substrate FNIP1. Holds under: One study in human cell lines (ESP2026). Full text not accessible when this link was written; the adaptor role is taken from the authors' abstract. plausible in people, not shown directly · emerging, few independent studies	M	ESP2026
TAX1BP1 recruits ULK1 mechanism: recruitment · this link in full · on the map table	TAX1BP1 can bring ULK1 to the lysosome instead of TBK1.The same adaptor, TAX1BP1, can bring ULK1 instead of TBK1 to stressed lysosomes; either kinase then phosphorylates FNIP1. Holds under: One study in human cell lines (ESP2026). Which kinase dominates in which cell type is not stated in the abstract. Full text not accessible when this link was written. plausible in people, not shown directly · emerging, few independent studies	M	ESP2026
v-ATPase recruits TAX1BP1 mechanism: recruitment · this link in full · on the map table	A stressed lysosome's proton pump calls in the helper protein TAX1BP1.Lysosomal stress acting through the v-ATPase proton pump brings the adaptor TAX1BP1 to the lysosome, where it docks the kinases TBK1 and ULK1. Recurrent ATP6V1B2 mutations in this pump, found in follicular lymphoma, keep the route switched on. This route is independent of nutrients and runs in parallel to amino-acid signalling through the same pump. Holds under: One study (ESP2026) in human cell lines and ATP6V1B2-mutant follicular lymphoma samples. How the v-ATPase recruits TAX1BP1 (direct contact or an intermediate) is not stated in the abstract, so the step is marked unresolved. Full text not accessible when this link was written. A stress route separate from the v-ATPase's role in amino-acid sensing (VATPASE-RAGULATOR). plausible in people, not shown directly · emerging, few independent studies	M	ESP2026

Evidence at a glance

Evidence	What it means	Studies
M	Molecular — cells, biochemistry, structure	1

No direct human evidence in the Atlas for this entity yet — everything below rests on animal or molecular work.

Studies

Year	Evidence	Study
2026	M	A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation. ESP2026 Identifies a nutrient-independent lysosomal pathway in which v-ATPase recruits TBK1/ULK1 to phosphorylate FNIP1, inhibiting the FLCN:FNIP complex and releasing TFEB for nuclear translocation; recurrent ATP6V1B2 mutations found in follicular lymphoma patients constitutively hyperactivate this axis, driving TFEB-dependent tumor proliferation.

Related entities

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Barton, O. (2026). TAX1BP1 [Entity page]. In Oliver's mTOR Atlas [Data set]. https://mtor-atlas.org/gene/tax1bp1/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_gene_tax1bp1,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}: TAX1BP1},
  howpublished = {Entity page in a data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/gene/tax1bp1/},
  doi          = {10.5281/zenodo.22059963}
}

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