Pathway link VATPASE-TAX1BP1

v-ATPase – TAX1BP1

v-ATPase recruits TAX1BP1.

A stressed lysosome's proton pump calls in the helper protein TAX1BP1.

Lysosomal stress acting through the v-ATPase proton pump brings the adaptor TAX1BP1 to the lysosome, where it docks the kinases TBK1 and ULK1. Recurrent ATP6V1B2 mutations in this pump, found in follicular lymphoma, keep the route switched on. This route is independent of nutrients and runs in parallel to amino-acid signalling through the same pump.

The conditions it holds under

One study (ESP2026) in human cell lines and ATP6V1B2-mutant follicular lymphoma samples. How the v-ATPase recruits TAX1BP1 (direct contact or an intermediate) is not stated in the abstract, so the step is marked unresolved. Full text not accessible when this link was written.

A stress route separate from the v-ATPase's role in amino-acid sensing (VATPASE-RAGULATOR).

Time it takes

minutes

Step

not yet resolved

Measured in

human cells

Where in the cell

lysosome

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

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