{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "4823f516b720e66843f0b75952daf5ccc5279a7c20c0cb7c0d1ac126ff6ca768",
  "corpus_snapshot": "2026-10-24T21:34:23+0200",
  "source_commit": "8f0f14a10e115daab72bb59e5bf8c63eda1daeb8",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "VATPASE-TAX1BP1",
  "claim": "v-ATPase recruits TAX1BP1",
  "source": {
   "name": "v-ATPase",
   "entity": "v-atpase"
  },
  "target": {
   "name": "TAX1BP1",
   "entity": "tax1bp1"
  },
  "effect": "recruits",
  "type": "recruitment",
  "directness": "unresolved",
  "timescale": "minutes",
  "compartment": "lyso",
  "map_band": "lyso",
  "species": [
   "human cells"
  ],
  "mechanism": "Lysosomal stress acting through the v-ATPase proton pump brings the adaptor TAX1BP1 to the lysosome, where it docks the kinases TBK1 and ULK1. Recurrent ATP6V1B2 mutations in this pump, found in follicular lymphoma, keep the route switched on. This route is independent of nutrients and runs in parallel to amino-acid signalling through the same pump.",
  "mechanism_beginner": "A stressed lysosome's proton pump calls in the helper protein TAX1BP1.",
  "context": "A stress route separate from the v-ATPase's role in amino-acid sensing (VATPASE-RAGULATOR).",
  "boundary": "One study (ESP2026) in human cell lines and ATP6V1B2-mutant follicular lymphoma samples. How the v-ATPase recruits TAX1BP1 (direct contact or an intermediate) is not stated in the abstract, so the step is marked unresolved. Full text not accessible when this link was written.",
  "boundary_tags": [
   "cell-line-only",
   "single-study"
  ],
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "plausible",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Genetic loss-of-function / rescue",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "ESP2026"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/VATPASE-TAX1BP1/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/VATPASE-TAX1BP1.json"
 }
}