Pathway link TAX1BP1-TBK1
TAX1BP1 TBK1
TAX1BP1 recruits TBK1.
TAX1BP1 brings the kinase TBK1 to the lysosome.
The conditions it holds under
One study in human cell lines (ESP2026). Full text not accessible when this link was written; the adaptor role is taken from the authors' abstract.
- Time it takes
- minutes
- Step
- direct (one molecule acts on the other)
- Measured in
- human cells
- Where in the cell
- lysosome
- Reaches people?
- plausible in people, not shown directly
- How settled
- emerging, few independent studies
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2026 | M | A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation.ESP2026 Identifies a nutrient-independent lysosomal pathway in which v-ATPase recruits TBK1/ULK1 to phosphorylate FNIP1, inhibiting the FLCN:FNIP complex and releasing TFEB for nuclear translocation; recurrent ATP6V1B2 mutations found in follicular lymphoma patients constitutively hyperactivate this axis, driving TFEB-dependent tumor proliferation. |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
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