Oliver's mTOR Atlas Evidence Platform
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Redefining the role of AMPK in autophagy and the energy stress response

Park JM, Lee DH, Kim DH · 2023 · Nature Communications · Atlas ID PAR2023

What this study shows

In cultured cells, AMPK activation under glucose starvation or mitochondrial energy stress inhibited ULK1 and autophagy induction, the opposite of the classic activating reading. AMPK also protected the ULK1 machinery from caspase-mediated degradation.

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Cultured human cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemCultured human cells
JournalNature Communications
Year2023
Peer reviewedYes
Record last updated2026-10-01
SourceDOI 10.1038/s41467-023-38401-z · PMID 37225695 · Free full text (PMC10209092)

In the Atlas

Links in the pathway map

Cite this paper

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Park, J. M., Lee, D. H., & Kim, D. H. (2023). Redefining the role of AMPK in autophagy and the energy stress response. Nature Communications. https://doi.org/10.1038/s41467-023-38401-z

@article{PAR2023,
  author       = {Park, J. M. and Lee, D. H. and Kim, D. H.},
  title        = {{Redefining the role of AMPK in autophagy and the energy stress response}},
  journal      = {Nature Communications},
  year         = {2023},
  doi          = {10.1038/s41467-023-38401-z},
  note         = {PMID: 37225695},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record PAR2023) [Data set]. https://mtor-atlas.org/study/PAR2023/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_PAR2023,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record PAR2023},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/PAR2023/},
  doi          = {10.5281/zenodo.22059963}
}
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