Do-Hyung Kim
Co-discovered raptor, the defining partner of mTOR in mTORC1, and then mLST8 (GbetaL) as a Sabatini-lab postdoc. His Minnesota lab identified PRAS40 as an insulin-regulated link to mTORC1 and studies how mTORC1 controls autophagy
Professor, Metabolic & Systems Biology, University of Minnesota · Postdoc, Whitehead Institute/MIT (Sabatini lab)
Kim Lab, University of Minnesota (Minneapolis, Minnesota, USA) ↗ ORCID0000-0002-2924-4370 ↗
Portrait: University of Minnesota College of Biological Sciences
Do-Hyung Kim did his postdoctoral work in David Sabatini's lab at the Whitehead Institute, where in 2002 he identified raptor (reported in parallel by the Yonezawa and Avruch labs), the partner protein that binds mTOR and makes the resulting complex — now called mTORC1 — sensitive to nutrients. The discovery gave the field its first molecular handle on what would become mTOR's two distinct complexes.
Kim went on to identify GbetaL (mLST8), a second core component shared by both mTOR complexes, and later helped characterize PRAS40 and other regulators that tune mTORC1 activity in response to insulin and amino acids. He now runs his own lab at the University of Minnesota, studying the wider mTOR signalling network in growth control and disease.
The timeline below follows Kim's contributions gathered in this Atlas.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2002 | M | mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery KIM2002 Identifies raptor, the defining partner protein that makes mTOR nutrient-sensitive and founds mTOR Complex 1. |
| 2003 | M | GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR KIM2003 Identifies GbetaL (mLST8), a positive regulator shared by both mTOR complexes. |
| 2004 | M | Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton SAR2004 Discovery of Rictor and the SECOND mTOR complex, mTORC2. Crucially showed this complex is NOT blocked by rapamycin and does not use Raptor - it controls the cytoskeleton via PKC. This is the paper that split mTOR biology into 'two faces' at the molecular level. |
| 2007 | M | Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 VAN2007 Insulin signals to mTORC1 through Akt phosphorylation of the inhibitor PRAS40. |
| 2012 | M | SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling KIM2012 Identifies SH3BP4 as a negative regulator that restrains Rag-GTPase signalling to mTORC1. |
Co-authors in the Atlas 9
People with a profile here who share at least one study with Do-Hyung Kim.
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- David M. Sabatini 3 shared studies Identified mTOR (as RAFT1) in 1994. His lab then mapped much of the machinery around it: raptor and rictor at the core of mTORC1 and mTORC2, the Rag–Ragulator system that docks mTORC1 on the lysosome, and the sensors that detect leucine, arginine and SAM
- Dos D. Sarbassov 3 shared studies Discovered rictor as a Sabatini-lab postdoc, in parallel with Michael Hall's lab, defining mTOR Complex 2, and showed that this complex is the long-sought kinase that phosphorylates Akt on serine 473. He also found that prolonged rapamycin treatment can block mTORC2 assembly
- Hediye Erdjument-Bromage 3 shared studies Ran the mass-spectrometry analyses in Paul Tempst's lab at Memorial Sloan Kettering that identified the unknown proteins in the raptor, mLST8 and rictor purifications, and contributed the same approach to work on how ERK inactivates TSC2
- Paul Tempst 3 shared studies Developed mass-spectrometry methods for identifying proteins from tiny samples, and led the Memorial Sloan Kettering proteomics laboratory that identified the unknown partners of mTOR in the raptor, mLST8 and rictor purifications
- Robert R. Latek 3 shared studies Bioinformatics scientist at the Whitehead Institute who worked on the Sabatini-lab papers that described raptor, mLST8 (GbetaL) and rictor (raptor and rictor were reported in parallel by other labs), the core partners of mTOR in its two complexes
- Siraj M. Ali 3 shared studies Worked in the Sabatini lab on the papers that discovered raptor, mLST8 and rictor, and on the finding that the rictor-mTOR complex phosphorylates Akt. He later moved into cancer genomics and clinical diagnostics
- David A. Guertin Built the mouse genetics that defined mTORC2's biological roles
- Emilie Vander Haar First author of the 2007 study identifying PRAS40 as the link that carries insulin signals from Akt to mTOR
- Young-Mi Kim mTOR researcher in Do-Hyung Kim's University of Minnesota lab who found SH3BP4 as a brake on the amino acid sensing Rag GTPases and showed that mTORC1 phosphorylates UVRAG to slow autophagy
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