SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling

Amino acids stimulate cell growth and suppress autophagy through activation of mTORC1. The activation of mTORC1 by amino acids is mediated by Rag guanosine triphosphatase (GTPase) heterodimers on the lysosome. The molecular mechanism by which amino acids regulate the Rag GTPase heterodimers remains to be elucidated. Here, we identify SH3 domain-binding protein 4 (SH3BP4) as a binding protein and a negative regulator of Rag GTPase complex.

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Kim, Y. M., et al. (2012). SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. Molecular cell. https://doi.org/10.1016/j.molcel.2012.04.007

@article{KIM2012,
  author       = {Kim, Y. M. and Kim, D. H. and others},
  title        = {{SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling}},
  journal      = {Molecular cell},
  year         = {2012},
  doi          = {10.1016/j.molcel.2012.04.007},
  note         = {PMID: 22575674},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record KIM2012) [Data set]. https://mtor-atlas.org/study/KIM2012/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_KIM2012,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record KIM2012},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/KIM2012/},
  doi          = {10.5281/zenodo.22059963}
}