SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling

Kim YM, Stone M, Hwang TH, Kim YG, Dunlevy JR, Griffin TJ, Kim DH · 2012 · Molecular cell · Atlas ID KIM2012

What this study shows

SH3BP4 negatively regulates amino-acid-Rag-GTPase-mTORC1 signalling.

Abstract

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Amino acids stimulate cell growth and suppress autophagy through activation of mTORC1. The activation of mTORC1 by amino acids is mediated by Rag guanosine triphosphatase (GTPase) heterodimers on the lysosome. The molecular mechanism by which amino acids regulate the Rag GTPase heterodimers remains to be elucidated. Here, we identify SH3 domain-binding protein 4 (SH3BP4) as a binding protein and a negative regulator of Rag GTPase complex.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Molecular cell
Year	2012
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.molcel.2012.04.007 · PMID 22575674 · Free full text (PMC3389276)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Biochemical/genetic (SH3BP4)
Target	SH3BP4 / Rag GTPase / mTORC1
Model	Mammalian cells
Effect	SH3BP4 is a negative regulator of amino-acid-Rag-GTPase-mTORC1 signaling

In the Atlas

Links in the pathway map

Supports Rag GTPases recruits mTORC1

Cite this paper

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Kim, Y. M., Stone, M., Hwang, T. H., Kim, Y. G., Dunlevy, J. R., Griffin, T. J., & Kim, D. H. (2012). SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. Molecular cell. https://doi.org/10.1016/j.molcel.2012.04.007

@article{KIM2012,
  author       = {Kim, Y. M. and Stone, M. and Hwang, T. H. and Kim, Y. G. and Dunlevy, J. R. and Griffin, T. J. and Kim, D. H.},
  title        = {{SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling}},
  journal      = {Molecular cell},
  year         = {2012},
  doi          = {10.1016/j.molcel.2012.04.007},
  note         = {PMID: 22575674},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record KIM2012) [Data set]. https://mtor-atlas.org/study/KIM2012/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_KIM2012,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record KIM2012},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/KIM2012/},
  doi          = {10.5281/zenodo.22059963}
}

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