Young-Mi Kim

mTOR researcher in Do-Hyung Kim's University of Minnesota lab who found SH3BP4 as a brake on the amino acid sensing Rag GTPases and showed that mTORC1 phosphorylates UVRAG to slow autophagy

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota (papers with Do-Hyung Kim, 2007–2016)

Young-Mi Kim is the first author of KIM2012, a Molecular Cell paper from Do-Hyung Kim's lab at the University of Minnesota. mTORC1, the growth-control complex, only works when it sits on the surface of the lysosome, and it is brought there by the Rag GTPases, switches that flip on when amino acids are plentiful. The study, done in human cells, found that the protein SH3BP4 binds the inactive form of the Rag complex when amino acids are scarce and keeps it from switching on. As a result mTORC1 stays away from the lysosome, its activity and cell growth drop, and autophagy, the cell's recycling system, goes up.

Kim followed this with a short 2012 review on SH3BP4 and other Rag binders in Molecules and Cells, and was first author of the lab's 2014 Molecular Cell paper showing that mTORC1 phosphorylates UVRAG, a protein that helps autophagosomes and endosomes mature. Phosphorylation of UVRAG slows that maturation, so mTORC1 brakes autophagy at a late step as well as at the start. Earlier papers in the same lab, from 2007 and 2009, include the discovery of PRR5 as a part of mTORC2 and the finding that mTOR phosphorylates the ULK-ATG13-FIP200 complex that starts autophagy.

These papers all list the University of Minnesota. Because this is a common name, only papers shared with Do-Hyung Kim at Minnesota were counted. No official profile was found, so the current position is not known and the affiliation shown is the one on the Atlas paper.

Milestones in the Atlas

A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.

Co-authors in the Atlas 1

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