The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease

The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such as the levels of nutrients, growth factors, energy sources and oxygen, and triggers responses that either boost anabolism or suppress catabolism. mTORC1 signalling has wide-ranging consequences for the growth and homeostasis of key tissues and organs, and its dysregulated activity promotes cancer, type 2 diabetes, neurodegeneration and other age-related disorders.

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Goul, C., Peruzzo, R., & Zoncu, R. (2023). The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease. Nature reviews. Molecular cell biology. https://doi.org/10.1038/s41580-023-00641-8

@article{GOU2023,
  author       = {Goul, C. and Peruzzo, R. and Zoncu, R.},
  title        = {{The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease}},
  journal      = {Nature reviews. Molecular cell biology},
  year         = {2023},
  doi          = {10.1038/s41580-023-00641-8},
  note         = {PMID: 37612414},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record GOU2023) [Data set]. https://mtor-atlas.org/study/GOU2023/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GOU2023,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GOU2023},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GOU2023/},
  doi          = {10.5281/zenodo.22059963}
}