Oliver's mTOR Atlas Evidence Platform
Reading level
Mode

Redox-sensitive mTOR-eIF4A signaling promotes selective P-glycoprotein translation.

Jin P, Jin M, Feng L, He J, Ying Y, Bai R et al. · 2026 · Free radical biology & medicine · Atlas ID JIN2026

What this study shows

Oxidative stress activates a redox-sensitive PI3K-AKT-mTORC1-eIF4A cascade that selectively promotes P-glycoprotein translation via cap-dependent mRNA engagement, revealing a transcription-independent mechanism of rapid multidrug resistance induction.

Abstract

ShowHide

Cells face a temporal gap in oxidative stress adaptation, in which acute insults require rapid protein synthesis before transcriptional responses are fully established. Low-dose glucosamine (GlcN) induces a transient intracellular oxidation-sensitive response and activates redox-sensitive PI3K-AKT-mTORC1 signaling, leading to increased P-glycoprotein (P-gp) abundance without a detectable increase in total ABCB1 mRNA.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Cell line) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemCell line
JournalFree radical biology & medicine
Year2026
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1016/j.freeradbiomed.2026.07.033 · PMID 42468714

Extracted findings

InterventionGlucosamine; redox stress
TargetmTORC1 / eIF4A / 4E-BP1
ModelCell line
EffectmTOR-eIF4A selectively upregulates P-gp translation under oxidative stress; multidrug resistance

In the Atlas

Related topics

P-glycoprotein (ABCB1)eIF4A

Cite this paper

ShowHide 
Jin, P., et al. (2026). Redox-sensitive mTOR-eIF4A signaling promotes selective P-glycoprotein translation. Free radical biology & medicine. https://doi.org/10.1016/j.freeradbiomed.2026.07.033

@article{JIN2026,
  author       = {Jin, P. and Jin, M. and Feng, L. and He, J. and Ying, Y. and Bai, R. and others},
  title        = {{Redox-sensitive mTOR-eIF4A signaling promotes selective P-glycoprotein translation}},
  journal      = {Free radical biology & medicine},
  year         = {2026},
  doi          = {10.1016/j.freeradbiomed.2026.07.033},
  note         = {PMID: 42468714},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record JIN2026) [Data set]. https://mtor-atlas.org/study/JIN2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_JIN2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record JIN2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/JIN2026/},
  doi          = {10.5281/zenodo.22059963}
}