Redox-sensitive mTOR-eIF4A signaling promotes selective P-glycoprotein translation.

Jin P, Jin M, Feng L, He J, Yin Y, Bai R, Feng T, Zhang T, Luo H, Ma X, Chen J, …, Luo L · 2026 · Free radical biology & medicine · Atlas ID JIN2026

What this study shows

Oxidative stress activates a redox-sensitive PI3K-AKT-mTORC1-eIF4A cascade that selectively promotes P-glycoprotein translation via cap-dependent mRNA engagement, revealing a transcription-independent mechanism of rapid multidrug resistance induction.

Abstract

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Cells face a temporal gap in oxidative stress adaptation, in which acute insults require rapid protein synthesis before transcriptional responses are fully established. Low-dose glucosamine (GlcN) induces a transient intracellular oxidation-sensitive response and activates redox-sensitive PI3K-AKT-mTORC1 signaling, leading to increased P-glycoprotein (P-gp) abundance without a detectable increase in total ABCB1 mRNA.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Cell line) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Cell line
Journal	Free radical biology & medicine
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.freeradbiomed.2026.07.033 · PMID 42468714

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Glucosamine; redox stress
Target	mTORC1 / eIF4A / 4E-BP1
Model	Cell line
Effect	mTOR-eIF4A selectively upregulates P-gp translation under oxidative stress; multidrug resistance

In the Atlas

Links in the pathway map

Supports Reactive oxygen species activates mTORC1

Cite this paper

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Jin, P., Jin, M., Feng, L., He, J., Yin, Y., Bai, R., Feng, T., Zhang, T., Luo, H., Ma, X., Chen, J., Hussain, S., Wan, S., Fang, Z., Wu, Y., & Luo, L. (2026). Redox-sensitive mTOR-eIF4A signaling promotes selective P-glycoprotein translation. Free radical biology & medicine. https://doi.org/10.1016/j.freeradbiomed.2026.07.033

@article{JIN2026,
  author       = {Jin, P. and Jin, M. and Feng, L. and He, J. and Yin, Y. and Bai, R. and Feng, T. and Zhang, T. and Luo, H. and Ma, X. and Chen, J. and Hussain, S. and Wan, S. and Fang, Z. and Wu, Y. and Luo, L.},
  title        = {{Redox-sensitive mTOR-eIF4A signaling promotes selective P-glycoprotein translation}},
  journal      = {Free radical biology & medicine},
  year         = {2026},
  doi          = {10.1016/j.freeradbiomed.2026.07.033},
  note         = {PMID: 42468714},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record JIN2026) [Data set]. https://mtor-atlas.org/study/JIN2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_JIN2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record JIN2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/JIN2026/},
  doi          = {10.5281/zenodo.22059963}
}

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