Cardioprotection and lifespan extension by the natural polyamine spermidine

Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation.

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Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., Harger, A., Schipke, J., Zimmermann, A., Schmidt, A., Tong, M., Ruckenstuhl, C., Dammbrueck, C., Gross, A. S., Herbst, V., Magnes, C., Trausinger, G., Narath, S., Meinitzer, A., Hu, Z., Kirsch, A., Eller, K., Carmona-Gutierrez, D., Buettner, S., Pietrocola, F., Knittelfelder, O., Schrepfer, E., Rockenfeller, P., Simonini, C., Rahn, A., Horsch, M., Moreth, K., Beckers, J., Fuchs, H., Gailus-Durner, V., Neff, F., Janik, D., Rathkolb, B., Rozman, J., de Angelis, M. H., Moustafa, T., Haemmerle, G., Mayr, M., Willeit, P., von Frieling-Salewsky, M., Pieske, B., Scorrano, L., Pieber, T., Pechlaner, R., Willeit, J., Sigrist, S. J., Linke, W. A., Muehlfeld, C., Sadoshima, J., Dengjel, J., Kiechl, S., Sedej, S., & Madeo, F. (2016). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. https://doi.org/10.1038/nm.4222

@article{EIS2016,
  author       = {Eisenberg, T. and Abdellatif, M. and Schroeder, S. and Primessnig, U. and Stekovic, S. and Pendl, T. and Harger, A. and Schipke, J. and Zimmermann, A. and Schmidt, A. and Tong, M. and Ruckenstuhl, C. and Dammbrueck, C. and Gross, A. S. and Herbst, V. and Magnes, C. and Trausinger, G. and Narath, S. and Meinitzer, A. and Hu, Z. and Kirsch, A. and Eller, K. and Carmona-Gutierrez, D. and Buettner, S. and Pietrocola, F. and Knittelfelder, O. and Schrepfer, E. and Rockenfeller, P. and Simonini, C. and Rahn, A. and Horsch, M. and Moreth, K. and Beckers, J. and Fuchs, H. and Gailus-Durner, V. and Neff, F. and Janik, D. and Rathkolb, B. and Rozman, J. and de Angelis, M. H. and Moustafa, T. and Haemmerle, G. and Mayr, M. and Willeit, P. and von Frieling-Salewsky, M. and Pieske, B. and Scorrano, L. and Pieber, T. and Pechlaner, R. and Willeit, J. and Sigrist, S. J. and Linke, W. A. and Muehlfeld, C. and Sadoshima, J. and Dengjel, J. and Kiechl, S. and Sedej, S. and Madeo, F.},
  title        = {{Cardioprotection and lifespan extension by the natural polyamine spermidine}},
  journal      = {Nat Med},
  year         = {2016},
  doi          = {10.1038/nm.4222},
  note         = {PMID: 27841876},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record EIS2016) [Data set]. https://mtor-atlas.org/study/EIS2016/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_EIS2016,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record EIS2016},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/EIS2016/},
  doi          = {10.5281/zenodo.22059963}
}