Didac Carmona-Gutierrez
Studies how cell death and autophagy shape ageing at the University of Graz, and contributed to the studies showing that spermidine extends lifespan through autophagy
Institute of Molecular Biosciences, University of Graz (affiliation on EIS2009 and EIS2016)
Institute of Molecular Biosciences, University of Graz (Graz, Austria) ↗ ORCID0000-0001-7548-7771 ↗
Portrait: University of Graz
Carmona-Gutierrez works in the Graz group on yeast as a model for programmed cell death and ageing, and on the compounds that shift the balance — the caloric-restriction mimetics of which spermidine is the best-characterised.
He is a co-author of both corpus papers on that branch: EIS2009, which showed the effect depends on autophagy and works through histone acetylation, and EIS2016, which moved it into mammals and tied the cardiac benefit to Atg5.
A second strand of his work is definitional: he is among the authors of the yeast cell death nomenclature guidelines and an editor in that literature. This matters more than it sounds, because most disputes in the autophagy field turn out to be disputes about what a measurement means.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2009 | A | Induction of autophagy by spermidine promotes longevity EIS2009 Co-author: spermidine extends lifespan in an autophagy-dependent way, via inhibition of histone acetyltransferases. |
| 2016 | A | Cardioprotection and lifespan extension by the natural polyamine spermidine EIS2016 Co-author: spermidine feeding extends mouse lifespan and preserves diastolic function in old animals. |
Co-authors in the Atlas
People with a profile here who share at least one study with Didac Carmona-Gutierrez.
- Frank Madeo 2 shared studies Established spermidine as a dietary compound that extends lifespan in yeast, worms, flies and mice, and showed that the effect depends on autophagy
- Christoph Magnes 2 shared studies Analytical chemist at Joanneum Research whose group contributed the mass-spectrometry measurements of polyamines in the Graz spermidine studies
- Christoph Ruckenstuhl 2 shared studies Yeast geneticist who works out how amino-acid restriction and vacuole acidity set lifespan
- Sabrina Büttner 2 shared studies Studies how organelles communicate inside cells and how that communication breaks down with age, and contributed to the Graz studies showing that spermidine extends lifespan by inducing autophagy
- Sabrina Schroeder 2 shared studies Researcher in Frank Madeo's group at Graz who has contributed to the spermidine studies from the first yeast longevity experiments to work in mice
- Tobias Eisenberg 2 shared studies Showed as first author that the dietary polyamine spermidine extends lifespan by inducing autophagy, and later that it protects the heart in an autophagy-dependent way
- Frauke Neff First author of the study that separated what rapamycin does to lifespan from what it does to ageing itself
- Junichi Sadoshima Studies how mTOR, autophagy and mitophagy protect the heart under stress and in ageing, and contributed to the finding that spermidine protects the heart