Didac Carmona-Gutierrez
Studies how cell death and autophagy shape ageing at the University of Graz, and contributed to the studies showing that spermidine extends lifespan through autophagy
Institute of Molecular Biosciences, University of Graz (affiliation on EIS2009 and EIS2016)
Institute of Molecular Biosciences, University of Graz (Graz, Austria) ↗ ORCID0000-0001-7548-7771 ↗
Portrait: University of Graz
Carmona-Gutierrez works in the Graz group on yeast as a model for programmed cell death and ageing, and on the compounds that shift the balance — the caloric-restriction mimetics of which spermidine is the best-characterised.
He is a co-author of both corpus papers on that branch: EIS2009, which showed the effect depends on autophagy and works through histone acetylation, and EIS2016, which moved it into mammals and tied the cardiac benefit to Atg5.
A second strand of his work is definitional: he is among the authors of the yeast cell death nomenclature guidelines and an editor in that literature. This matters more than it sounds, because most disputes in the autophagy field turn out to be disputes about what a measurement means.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2009 | A | Induction of autophagy by spermidine promotes longevity EIS2009 Co-author: spermidine extends lifespan in an autophagy-dependent way, via inhibition of histone acetyltransferases. |
| 2016 | A | Cardioprotection and lifespan extension by the natural polyamine spermidine EIS2016 Co-author: spermidine feeding extends mouse lifespan and preserves diastolic function in old animals. |
Co-authors in the Atlas 20
People with a profile here who share at least one study with Didac Carmona-Gutierrez.
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- Frank Madeo 2 shared studies Established spermidine as a dietary compound that extends lifespan in yeast, worms, flies and mice, and showed that the effect depends on autophagy
- Christoph Magnes 2 shared studies Analytical chemist at Joanneum Research whose group contributed the mass-spectrometry measurements of polyamines in the Graz spermidine studies
- Christoph Ruckenstuhl 2 shared studies Yeast geneticist who works out how amino-acid restriction and vacuole acidity set lifespan
- Sabrina Büttner 2 shared studies Studies how organelles communicate inside cells and how that communication breaks down with age, and contributed to the Graz studies showing that spermidine extends lifespan by inducing autophagy
- Sabrina Schroeder 2 shared studies Researcher in Frank Madeo's group at Graz who has contributed to the spermidine studies from the first yeast longevity experiments to work in mice
- Tobias Eisenberg 2 shared studies Showed as first author that the dietary polyamine spermidine extends lifespan by inducing autophagy, and later that it protects the heart in an autophagy-dependent way
- Birgit Rathkolb Scientist at the German Mouse Clinic of Helmholtz Munich and the Gene Center of LMU Munich who contributes to the clinic's phenotyping of mouse models
- Frauke Neff First author of the study that separated what rapamycin does to lifespan from what it does to ageing itself
- Guido Kroemer Cell biologist known for work on programmed cell death, mitochondria and autophagy, and for linking autophagy to ageing and cancer immunity.
- Helmut Fuchs Scientific and technical head of the German Mouse Clinic at Helmholtz Munich, the standardised many-organ testing platform for mouse models that Fuchs helped build
- Jan Rozman Scientist who worked at the German Mouse Clinic of Helmholtz Munich on the standardised phenotyping of mouse models
- Johannes Beckers Geneticist at Helmholtz Munich and the Technical University of Munich whose group at the Institute of Experimental Genetics runs gene-expression profiling for the German Mouse Clinic
- Jörn Dengjel Mass-spectrometry proteomics specialist in autophagy and protein homeostasis; co-author on the TBK1/ULK1–TFEB lysosomal stress pathway and on the spermidine lifespan and cardioprotection study.
- Junichi Sadoshima Studies how mTOR, autophagy and mitophagy protect the heart under stress and in ageing, and contributed to the finding that spermidine protects the heart
- Kristin Moreth Scientist at the German Mouse Clinic of Helmholtz Munich who contributed to its phenotyping of mouse models, including heart measurements
- Luca Scorrano Mitochondrial biologist known for showing how the shape of mitochondria and their inner folds (cristae) control energy production and cell death.
- Marion Horsch Scientist at the Institute of Experimental Genetics, Helmholtz Munich, who has worked with Johannes Beckers on gene-expression studies of mouse models for the German Mouse Clinic
- Martin Hrabě de Angelis Mouse geneticist who directs large-scale phenotyping of mouse mutants and the German Mouse Clinic, a platform that tests how genes affect health and disease.
- Nektarios Tavernarakis Geneticist who uses the roundworm C. elegans to study how ageing, neurodegeneration, necrotic cell death, autophagy and protein turnover are controlled
- Valérie Gailus-Durner Biochemist who co-founded the German Mouse Clinic at Helmholtz Munich and leads it as scientific head, running standardised testing of mouse models across many organ systems
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