Martin Hrabě de Angelis
Mouse geneticist who directs large-scale phenotyping of mouse mutants and the German Mouse Clinic, a platform that tests how genes affect health and disease.
Director, Institute of Experimental Genetics, Helmholtz Munich (since 2000) · Chair of Experimental Genetics, Technical University of Munich (since 2003) · Research Director, Helmholtz Munich · Member, Leopoldina (2018) · Paul Langerhans Medal (2021)
Portrait: Helmholtz Munich
Martin Hrabě de Angelis leads the Institute of Experimental Genetics at Helmholtz Munich and holds the chair of experimental genetics at the Technical University of Munich. His institute runs systematic, standardized health checks on mice, covering heart, metabolism, behaviour and more, so that the effects of a gene or a treatment can be measured across the whole animal.
That expertise is why he appears on the 2016 Nature Medicine paper from Frank Madeo's group in the Atlas. The study found that spermidine, a natural polyamine, extended lifespan in mice and protected the heart from age-related stiffening and thickening. Mouse phenotyping platforms like his are what make claims about whole-body effects checkable.
He is also a founding member and board chair of the German Center for Diabetes Research, a member of the executive committee of the International Mouse Phenotyping Consortium, and a member of the Leopoldina, Germany's national academy of sciences.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2016 | A | Cardioprotection and lifespan extension by the natural polyamine spermidine EIS2016 Co-author on the spermidine study, in which oral spermidine extended mouse lifespan and improved cardiac function; the mouse phenotyping work is his field. |
Co-authors in the Atlas
People with a profile here who share at least one study with Martin Hrabě de Angelis.
- Didac Carmona-Gutierrez Studies how cell death and autophagy shape ageing at the University of Graz, and contributed to the studies showing that spermidine extends lifespan through autophagy
- Frank Madeo Established spermidine as a dietary compound that extends lifespan in yeast, worms, flies and mice, and showed that the effect depends on autophagy
- Frauke Neff First author of the study that separated what rapamycin does to lifespan from what it does to ageing itself
- Christoph Magnes Analytical chemist at Joanneum Research whose group contributed the mass-spectrometry measurements of polyamines in the Graz spermidine studies
- Christoph Ruckenstuhl Yeast geneticist who works out how amino-acid restriction and vacuole acidity set lifespan
- Jörn Dengjel Mass-spectrometry proteomics specialist in autophagy and protein homeostasis; co-author on the TBK1/ULK1–TFEB lysosomal stress pathway and on the spermidine lifespan and cardioprotection study.
- Junichi Sadoshima Studies how mTOR, autophagy and mitophagy protect the heart under stress and in ageing, and contributed to the finding that spermidine protects the heart
- Luca Scorrano Mitochondrial biologist known for showing how the shape of mitochondria and their inner folds (cristae) control energy production and cell death.
- Sabrina Büttner Studies how organelles communicate inside cells and how that communication breaks down with age, and contributed to the Graz studies showing that spermidine extends lifespan by inducing autophagy
- Sabrina Schroeder Researcher in Frank Madeo's group at Graz who has contributed to the spermidine studies from the first yeast longevity experiments to work in mice
- Tobias Eisenberg Showed as first author that the dietary polyamine spermidine extends lifespan by inducing autophagy, and later that it protects the heart in an autophagy-dependent way
Every researcher with a profile →
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