Frauke Neff
First author of the study that separated what rapamycin does to lifespan from what it does to ageing itself
Neuropathologist, Institute of Pathology, München Klinik Neuperlach · head of pathology, German Mouse Clinic, Helmholtz Zentrum München (from 2009) · habilitation in neuropathology, Technical University of Munich (2016) · MD, University of Marburg
Portrait: Technical University of Munich, Institute of Pathology
NEF2013 is one of the more uncomfortable papers in this corpus, and one of the more useful. Rapamycin does extend murine lifespan — that part replicated. But when the same mice were put through a broad phenotyping battery covering many age-sensitive traits, most of them were not rejuvenated. Some of what looked like an anti-ageing effect was better explained as a direct pharmacological effect that happens to be beneficial.
The result is a boundary condition the Atlas keeps in view whenever the lifespan literature is quoted: living longer and ageing more slowly are separate claims that need separate evidence, and a single survival curve does not settle the second one.
She also appears in EIS2016 through the German Mouse Clinic's phenotyping of the spermidine-fed animals — the same discipline applied to a different intervention.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2013 | A | Rapamycin extends murine lifespan but has limited effects on aging NEF2013 First author: rapamycin extended lifespan in mice while leaving most age-sensitive phenotypes unchanged, separating lifespan from ageing. |
| 2016 | A | Cardioprotection and lifespan extension by the natural polyamine spermidine EIS2016 Co-author: contributed to the German Mouse Clinic phenotyping of spermidine-treated mice. |
Co-authors in the Atlas 19
People with a profile here who share at least one study with Frauke Neff.
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- Birgit Rathkolb 2 shared studies Scientist at the German Mouse Clinic of Helmholtz Munich and the Gene Center of LMU Munich who contributes to the clinic's phenotyping of mouse models
- Helmut Fuchs 2 shared studies Scientific and technical head of the German Mouse Clinic at Helmholtz Munich, the standardised many-organ testing platform for mouse models that Fuchs helped build
- Jan Rozman 2 shared studies Scientist who worked at the German Mouse Clinic of Helmholtz Munich on the standardised phenotyping of mouse models
- Johannes Beckers 2 shared studies Geneticist at Helmholtz Munich and the Technical University of Munich whose group at the Institute of Experimental Genetics runs gene-expression profiling for the German Mouse Clinic
- Kristin Moreth 2 shared studies Scientist at the German Mouse Clinic of Helmholtz Munich who contributed to its phenotyping of mouse models, including heart measurements
- Marion Horsch 2 shared studies Scientist at the Institute of Experimental Genetics, Helmholtz Munich, who has worked with Johannes Beckers on gene-expression studies of mouse models for the German Mouse Clinic
- Valérie Gailus-Durner 2 shared studies Biochemist who co-founded the German Mouse Clinic at Helmholtz Munich and leads it as scientific head, running standardised testing of mouse models across many organ systems
- Dan Ehninger Showed that rapamycin reverses learning deficits in adult mice carrying a tuberous sclerosis mutation, and later tested carefully whether rapamycin's lifespan effect reflects a true slowing of ageing
- Didac Carmona-Gutierrez Studies how cell death and autophagy shape ageing at the University of Graz, and contributed to the studies showing that spermidine extends lifespan through autophagy
- Frank Madeo Established spermidine as a dietary compound that extends lifespan in yeast, worms, flies and mice, and showed that the effect depends on autophagy
- Christoph Magnes Analytical chemist at Joanneum Research whose group contributed the mass-spectrometry measurements of polyamines in the Graz spermidine studies
- Christoph Ruckenstuhl Yeast geneticist who works out how amino-acid restriction and vacuole acidity set lifespan
- Jörn Dengjel Mass-spectrometry proteomics specialist in autophagy and protein homeostasis; co-author on the TBK1/ULK1–TFEB lysosomal stress pathway and on the spermidine lifespan and cardioprotection study.
- Junichi Sadoshima Studies how mTOR, autophagy and mitophagy protect the heart under stress and in ageing, and contributed to the finding that spermidine protects the heart
- Luca Scorrano Mitochondrial biologist known for showing how the shape of mitochondria and their inner folds (cristae) control energy production and cell death.
- Martin Hrabě de Angelis Mouse geneticist who directs large-scale phenotyping of mouse mutants and the German Mouse Clinic, a platform that tests how genes affect health and disease.
- Sabrina Büttner Studies how organelles communicate inside cells and how that communication breaks down with age, and contributed to the Graz studies showing that spermidine extends lifespan by inducing autophagy
- Sabrina Schroeder Researcher in Frank Madeo's group at Graz who has contributed to the spermidine studies from the first yeast longevity experiments to work in mice
- Tobias Eisenberg Showed as first author that the dietary polyamine spermidine extends lifespan by inducing autophagy, and later that it protects the heart in an autophagy-dependent way
Every researcher with a profile →
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