Rapamycin extends murine lifespan but has limited effects on aging

Aging is a major risk factor for a large number of disorders and functional impairments. Therapeutic targeting of the aging process may therefore represent an innovative strategy in the quest for novel and broadly effective treatments against age-related diseases. The recent report of lifespan extension in mice treated with the FDA-approved mTOR inhibitor rapamycin represented the first demonstration of pharmacological extension of maximal lifespan in mammals.

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Neff, F., Flores-Dominguez, D., Ryan, D. P., Horsch, M., Schröder, S., Adler, T., Afonso, L. C., Aguilar-Pimentel, J. A., Becker, L., Garrett, L., Hans, W., Hettich, M. M., Holtmeier, R., Hölter, S. M., Moreth, K., Prehn, C., Puk, O., Rácz, I., Rathkolb, B., Rozman, J., Naton, B., Ordemann, R., Adamski, J., Beckers, J., Bekeredjian, R., Busch, D. H., Ehninger, G., Graw, J., Höfler, H., Klingenspor, M., Klopstock, T., Ollert, M., Stypmann, J., Wolf, E., Wurst, W., Zimmer, A., Fuchs, H., Gailus-Durner, V., Hrabe de Angelis, M., & Ehninger, D. (2013). Rapamycin extends murine lifespan but has limited effects on aging. The Journal of clinical investigation. https://doi.org/10.1172/JCI67674

@article{NEF2013,
  author       = {Neff, F. and Flores-Dominguez, D. and Ryan, D. P. and Horsch, M. and Schröder, S. and Adler, T. and Afonso, L. C. and Aguilar-Pimentel, J. A. and Becker, L. and Garrett, L. and Hans, W. and Hettich, M. M. and Holtmeier, R. and Hölter, S. M. and Moreth, K. and Prehn, C. and Puk, O. and Rácz, I. and Rathkolb, B. and Rozman, J. and Naton, B. and Ordemann, R. and Adamski, J. and Beckers, J. and Bekeredjian, R. and Busch, D. H. and Ehninger, G. and Graw, J. and Höfler, H. and Klingenspor, M. and Klopstock, T. and Ollert, M. and Stypmann, J. and Wolf, E. and Wurst, W. and Zimmer, A. and Fuchs, H. and Gailus-Durner, V. and Hrabe de Angelis, M. and Ehninger, D.},
  title        = {{Rapamycin extends murine lifespan but has limited effects on aging}},
  journal      = {The Journal of clinical investigation},
  year         = {2013},
  doi          = {10.1172/JCI67674},
  note         = {PMID: 23863708},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record NEF2013) [Data set]. https://mtor-atlas.org/study/NEF2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_NEF2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record NEF2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/NEF2013/},
  doi          = {10.5281/zenodo.22059963}
}