Dan Ehninger
Showed that rapamycin reverses learning deficits in adult mice carrying a tuberous sclerosis mutation, and later tested carefully whether rapamycin's lifespan effect reflects a true slowing of ageing
Group Leader, DZNE Bonn (since 2010) · postdoc, UCLA (Alcino Silva lab, 2004–2009) · MD, Charité Berlin/UCL/Mount Sinai/Harvard (clinical training)
Translational Biogerontology Group, DZNE Bonn (Bonn, Germany) ↗
Portrait: DZNE
As UCLA postdoc, showed (EHN2008) Tsc2+/- mice have hyperactive mTOR/hippocampal learning deficits, reversible with a short rapamycin course — an early demonstration mTOR drugs could treat cognitive symptoms of a genetic disorder. At DZNE, led a rigorous large-scale phenotyping study (NEF2013): rapamycin extends mouse lifespan but leaves most classic aging phenotypes unchanged — a standard citation distinguishing 'longer life' from 'slower aging.'
Physician trained in neurology before full-time research; DZNE group continues skeptical, rigorous mouse-aging science.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2008 | A | Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis EHN2008 Rapamycin reverses hippocampal learning/memory deficits in Tsc2+/- mice. |
| 2013 | A | Rapamycin extends murine lifespan but has limited effects on aging NEF2013 Rapamycin extends lifespan but leaves most classic aging markers unchanged. |
Co-authors in the Atlas 10
People with a profile here who share at least one study with Dan Ehninger.
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- Alcino J. Silva Studies the molecular and cellular basis of learning and memory, including how overactive mTOR signaling in tuberous sclerosis impairs memory and how rapamycin can reverse it in mice.
- Birgit Rathkolb Scientist at the German Mouse Clinic of Helmholtz Munich and the Gene Center of LMU Munich who contributes to the clinic's phenotyping of mouse models
- David J. Kwiatkowski Geneticist and physician who studies tuberous sclerosis complex (TSC) and the TSC1/TSC2 genes that restrain mTORC1.
- Frauke Neff First author of the study that separated what rapamycin does to lifespan from what it does to ageing itself
- Helmut Fuchs Scientific and technical head of the German Mouse Clinic at Helmholtz Munich, the standardised many-organ testing platform for mouse models that Fuchs helped build
- Jan Rozman Scientist who worked at the German Mouse Clinic of Helmholtz Munich on the standardised phenotyping of mouse models
- Johannes Beckers Geneticist at Helmholtz Munich and the Technical University of Munich whose group at the Institute of Experimental Genetics runs gene-expression profiling for the German Mouse Clinic
- Kristin Moreth Scientist at the German Mouse Clinic of Helmholtz Munich who contributed to its phenotyping of mouse models, including heart measurements
- Marion Horsch Scientist at the Institute of Experimental Genetics, Helmholtz Munich, who has worked with Johannes Beckers on gene-expression studies of mouse models for the German Mouse Clinic
- Valérie Gailus-Durner Biochemist who co-founded the German Mouse Clinic at Helmholtz Munich and leads it as scientific head, running standardised testing of mouse models across many organ systems
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