Tarek Moustafa
Researcher in hepatic metabolism and bile acid signaling
University Assistant (Univ.-Ass. Dr. rer. nat.), Division of Gastroenterology and Hepatology, Medical University of Graz, Austria
Tarek Moustafa is a University Assistant in the Division of Gastroenterology and Hepatology at the Medical University of Graz, working on metabolic regulation in the liver, including bile acid and nutrient-signaling pathways.
Senior/corresponding author of a 2026 Science Advances study showing that hepatic mTORC1-TFEB/TFE3 signaling state drives bile-acid diversification during metabolic adaptation, with effects reversed by rapamycin treatment or dietary protein restriction and correlating with metabolic outcomes in human MASLD patients.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | mTORC1-TFEB/TFE3 signaling is associated with bile acid diversification during hepatic metabolic adaptation ZAU2026 Senior/corresponding author: mTORC1-TFEB/TFE3 signaling shapes hepatic bile-acid metabolism, reversible by rapamycin and protein restriction, with correlation to human MASLD outcomes. |
Co-authors in the Atlas
People with a profile here who share at least one study with Tarek Moustafa.
- Alex Zaufel Researcher studying bile acid metabolism and mTORC1 signaling in liver disease
- Andrea Ballabio Discovered that the transcription factor TFEB is a master switch for building lysosomes and for autophagy. His lab was one of the groups that showed in 2012 that mTORC1 keeps TFEB out of the nucleus from the lysosome surface, and later (2020) that constitutive TFEB activation drives the kidney disease of Birt-Hogg-Dubé syndrome