Recurrent PIK3CA-E545K mutation promotes cervical cancer growth and invasion via AKT/mTOR signaling.

Huang C, Zhang W, Ma X, Li X, Sun X · 2026 · Molecular genetics and genomics · Atlas ID HUANG2026

What this study shows

PIK3CA-E545K hotspot mutation enhances cervical cancer cell proliferation and invasion by activating AKT/mTOR signaling, validated in xenograft models.

Abstract

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Cervical cancer remains a leading cause of cancer-related morbidity and mortality among women worldwide. Although genomic alterations in oncogenic signaling pathways have been implicated in cervical carcinogenesis, the functional impact of recurrent driver mutations remains incompletely understood. Whole-exome sequencing was performed on paired tumor and matched non-tumor tissues from 61 patients to identify recurrent somatic alterations.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Human (cancer cell lines + xenograft)) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Human (cancer cell lines + xenograft)
Journal	Molecular genetics and genomics
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1007/s00438-026-02495-z · PMID 42562966

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	PIK3CA-E545K mutation
Target	AKT/mTOR
Model	Human
Effect	Promotes tumor cell proliferation and invasion

In the Atlas

Cite this paper

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Huang, C., Zhang, W., Ma, X., Li, X., & Sun, X. (2026). Recurrent PIK3CA-E545K mutation promotes cervical cancer growth and invasion via AKT/mTOR signaling. Molecular genetics and genomics. https://doi.org/10.1007/s00438-026-02495-z

@article{HUANG2026,
  author       = {Huang, C. and Zhang, W. and Ma, X. and Li, X. and Sun, X.},
  title        = {{Recurrent PIK3CA-E545K mutation promotes cervical cancer growth and invasion via AKT/mTOR signaling}},
  journal      = {Molecular genetics and genomics},
  year         = {2026},
  doi          = {10.1007/s00438-026-02495-z},
  note         = {PMID: 42562966},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record HUANG2026) [Data set]. https://mtor-atlas.org/study/HUANG2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_HUANG2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record HUANG2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/HUANG2026/},
  doi          = {10.5281/zenodo.22059963}
}

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