Oliver's mTOR Atlas Evidence Platform
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Recurrent PIK3CA-E545K mutation promotes cervical cancer growth and invasion via AKT/mTOR signaling.

Huang C, Zhang W, Ma X, Li X, Sun X · 2026 · Molecular genetics and genomics · Atlas ID HUANG2026

What this study shows

PIK3CA-E545K hotspot mutation enhances cervical cancer cell proliferation and invasion by activating AKT/mTOR signaling, validated in xenograft models.

Abstract

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Cervical cancer remains a leading cause of cancer-related morbidity and mortality among women worldwide. Whole-exome sequencing was performed on paired tumor and matched non-tumor tissues from 61 patients to identify recurrent somatic alterations. Functional significance was subsequently evaluated using cervical cancer cell models. Genomic profiling identified PIK3CA as one of the most frequently mutated genes in cervical cancer. Functional analyses demonstrated that PIK3CA E545K mutation significantly enhanced tumor cell proliferation and invasive capacity while suppressing apoptosis.

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At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Human (cancer cell lines + xenograft)) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemHuman (cancer cell lines + xenograft)
JournalMolecular genetics and genomics
Year2026
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1007/s00438-026-02495-z

Extracted findings

InterventionPIK3CA-E545K mutation
TargetAKT/mTOR
ModelHuman
EffectPromotes tumor cell proliferation and invasion

In the Atlas

Related topics

PIK3CA

Cite this paper

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Huang, C., Zhang, W., Ma, X., Li, X., & Sun, X. (2026). Recurrent PIK3CA-E545K mutation promotes cervical cancer growth and invasion via AKT/mTOR signaling. Molecular genetics and genomics. https://doi.org/10.1007/s00438-026-02495-z

@article{HUANG2026,
  author       = {Huang, C. and Zhang, W. and Ma, X. and Li, X. and Sun, X.},
  title        = {{Recurrent PIK3CA-E545K mutation promotes cervical cancer growth and invasion via AKT/mTOR signaling}},
  journal      = {Molecular genetics and genomics},
  year         = {2026},
  doi          = {10.1007/s00438-026-02495-z},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record HUANG2026) [Data set]. https://mtor-atlas.org/study/HUANG2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_HUANG2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record HUANG2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/HUANG2026/},
  doi          = {10.5281/zenodo.22059963}
}