Xiaoge Sun
Senior author of a 2026 study showing that the recurrent PIK3CA-E545K mutation drives cervical cancer growth and invasion through AKT/mTOR signalling
Department of Radiation Oncology · Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China
Xiaoge Sun is the corresponding author of a 2026 study that sequenced paired tumor/non-tumor tissue from 61 cervical cancer patients and found PIK3CA among the most frequently mutated genes. In cell and mouse xenograft models, the mutant boosted tumor cell proliferation and invasiveness while suppressing apoptosis, acting through sustained AKT/mTOR pathway activation — supporting PI3K/AKT/mTOR-axis inhibitors as a rational therapeutic strategy for this cervical cancer subgroup.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2026 | M | Recurrent PIK3CA-E545K mutation promotes cervical cancer growth and invasion via AKT/mTOR signaling. HUANG2026 Corresponding author on genomic and functional work showing the PIK3CA-E545K mutation drives cervical cancer growth and invasion through sustained AKT/mTOR pathway activation. |