RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM · 1998 · Proceedings of the National Academy of Sciences of the United States of America · Atlas ID BUR1998

What this study shows

RAFT1/mTOR directly phosphorylates p70 S6K (Thr389) and 4E-BP1, the two central translational effectors.

Abstract

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The complex of rapamycin with its intracellular receptor, FKBP12, interacts with RAFT1/FRAP/mTOR, the in vivo rapamycin-sensitive target and a member of the ataxia telangiectasia mutated (ATM)-related family of kinases that share homology with the catalytic domain of phosphatidylinositol 3-kinase. The function of RAFT1 in the rapamycin-sensitive pathway and its connection to downstream components of the pathway, such as p70 S6 kinase and 4E-BP1, are poorly understood.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: In vitro) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	In vitro
Journal	Proceedings of the National Academy of Sciences of the United States of America
Year	1998
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1073/pnas.95.4.1432 · PMID 9465032 · Free full text (PMC19032)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Biochemical (in vitro kinase assay)
Target	RAFT1/mTOR / p70 S6K / 4E-BP1
Model	In vitro
Effect	RAFT1/mTOR directly phosphorylates p70 S6K and 4E-BP1 – connects mTOR to translational regulators

In the Atlas

Links in the pathway map

Supports mTORC1 inhibits 4E-BP1
Supports mTORC1 activates S6K1

Cite this paper

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Burnett, P. E., Barrow, R. K., Cohen, N. A., Snyder, S. H., & Sabatini, D. M. (1998). RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.95.4.1432

@article{BUR1998,
  author       = {Burnett, P. E. and Barrow, R. K. and Cohen, N. A. and Snyder, S. H. and Sabatini, D. M.},
  title        = {{RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1}},
  journal      = {Proceedings of the National Academy of Sciences of the United States of America},
  year         = {1998},
  doi          = {10.1073/pnas.95.4.1432},
  note         = {PMID: 9465032},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record BUR1998) [Data set]. https://mtor-atlas.org/study/BUR1998/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BUR1998,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BUR1998},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BUR1998/},
  doi          = {10.5281/zenodo.22059963}
}

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