TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

Mutation in the TSC2 tumor suppressor causes tuberous sclerosis complex, a disease characterized by hamartoma formation in multiple tissues. TSC2 inhibits cell growth by acting as a GTPase-activating protein toward Rheb, thereby inhibiting mTOR, a central controller of cell growth. Here, we show that Wnt activates mTOR via inhibiting GSK3 without involving beta-catenin-dependent transcription. GSK3 inhibits the mTOR pathway by phosphorylating TSC2 in a manner dependent on AMPK-priming phosphorylation.

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Inoki, K., et al. (2006). TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. https://doi.org/10.1016/j.cell.2006.06.055

@article{INO2006,
  author       = {Inoki, K. and Guan, K. L. and others},
  title        = {{TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth}},
  journal      = {Cell},
  year         = {2006},
  doi          = {10.1016/j.cell.2006.06.055},
  note         = {PMID: 16959574},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record INO2006) [Data set]. https://mtor-atlas.org/study/INO2006/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_INO2006,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record INO2006},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/INO2006/},
  doi          = {10.5281/zenodo.22059963}
}