The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

The mammalian target of rapamycin (mTOR) controls multiple cellular functions in response to amino acids and growth factors, in part by regulating the phosphorylation of p70 S6 kinase (p70S6k) and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1). Raptor (regulatory associated protein of mTOR) is a recently identified mTOR binding partner that also binds p70S6k and 4E-BP1 and is essential for TOR signaling in vivo.

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Nojima, H., et al. (2003). The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. The Journal of biological chemistry. https://doi.org/10.1074/jbc.C200665200

@article{NOJ2003,
  author       = {Nojima, H. and Yonezawa, K. and others},
  title        = {{The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif}},
  journal      = {The Journal of biological chemistry},
  year         = {2003},
  doi          = {10.1074/jbc.C200665200},
  note         = {PMID: 12604610},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record NOJ2003) [Data set]. https://mtor-atlas.org/study/NOJ2003/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_NOJ2003,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record NOJ2003},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/NOJ2003/},
  doi          = {10.5281/zenodo.22059963}
}