The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

Nojima H, Tokunaga C, Eguchi S, Oshiro N, Hidayat S, Yoshino K, Hara K, Tanaka N, Avruch J, Yonezawa K · 2003 · The Journal of biological chemistry · Atlas ID NOJ2003

What this study shows

Raptor binds mTOR substrates via their TOS motifs, acting as the substrate-presenting scaffold of mTORC1.

Abstract

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The mammalian target of rapamycin (mTOR) controls multiple cellular functions in response to amino acids and growth factors, in part by regulating the phosphorylation of p70 S6 kinase (p70S6k) and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1). Raptor (regulatory associated protein of mTOR) is a recently identified mTOR binding partner that also binds p70S6k and 4E-BP1 and is essential for TOR signaling in vivo.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: In vitro) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	In vitro
Journal	The Journal of biological chemistry
Year	2003
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1074/jbc.C200665200 · PMID 12604610

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Biochemical (TOS motif)
Target	mTOR / raptor / p70 S6K / 4E-BP1
Model	In vitro
Effect	Raptor binds the mTOR substrates p70 S6K and 4E-BP1 through their TOR-signaling (TOS) motif

In the Atlas

Links in the pathway map

Cite this paper

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Nojima, H., Tokunaga, C., Eguchi, S., Oshiro, N., Hidayat, S., Yoshino, K., Hara, K., Tanaka, N., Avruch, J., & Yonezawa, K. (2003). The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. The Journal of biological chemistry. https://doi.org/10.1074/jbc.C200665200

@article{NOJ2003,
  author       = {Nojima, H. and Tokunaga, C. and Eguchi, S. and Oshiro, N. and Hidayat, S. and Yoshino, K. and Hara, K. and Tanaka, N. and Avruch, J. and Yonezawa, K.},
  title        = {{The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif}},
  journal      = {The Journal of biological chemistry},
  year         = {2003},
  doi          = {10.1074/jbc.C200665200},
  note         = {PMID: 12604610},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record NOJ2003) [Data set]. https://mtor-atlas.org/study/NOJ2003/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_NOJ2003,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record NOJ2003},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/NOJ2003/},
  doi          = {10.5281/zenodo.22059963}
}

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