Constitutive mTORC1 Activation in Skeletal Muscle Increases Inflammation but is not Sufficient to Impair Glucose Tolerance.

Aberrant mTORC1 signaling in skeletal muscle has been implicated in aging and insulin resistance, however, it is not known whether chronic mTORC1 activation directly causes glucose intolerance. We tested the hypothesis that constitutive mTORC1 activation in mouse skeletal muscle impairs glucose homeostasis using tamoxifen-inducible, muscle-specific GATOR1 complex knockout.

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Marchant, E. D., et al. (2026). Constitutive mTORC1 Activation in Skeletal Muscle Increases Inflammation but is not Sufficient to Impair Glucose Tolerance. Function (Oxford, England). https://doi.org/10.1152/function.039.2026

@article{MARCHANT2026,
  author       = {Marchant, E. D. and Kalenta, H. and Kilroe, S. P. and May, J. and Martini, W. Z. and Weldon, K. S. and others},
  title        = {{Constitutive mTORC1 Activation in Skeletal Muscle Increases Inflammation but is not Sufficient to Impair Glucose Tolerance}},
  journal      = {Function (Oxford, England)},
  year         = {2026},
  doi          = {10.1152/function.039.2026},
  note         = {PMID: 42468920},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record MARCHANT2026) [Data set]. https://mtor-atlas.org/study/MARCHANT2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_MARCHANT2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record MARCHANT2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/MARCHANT2026/},
  doi          = {10.5281/zenodo.22059963}
}