Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function

Tuberous sclerosis (TSC) is a hamartoma syndrome attributable to mutations in either TSC1 or TSC2 in which brain involvement causes epilepsy, mental retardation, and autism. We have reported recently a mouse neuronal model of TSC in which Tsc1 is ablated in most neurons during cortical development. We have tested rapamycin and RAD001, both mammalian target of rapamycin mTORC1 inhibitors, as potential therapeutic agents in this model. Median survival is improved from 33 d to more than 100 d; behavior, phenotype, and weight gain are all also markedly improved.

Read the full abstract on PubMed →

Meikle, L., et al. (2008). Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. The Journal of neuroscience. https://doi.org/10.1523/JNEUROSCI.0955-08.2008

@article{MEI2008,
  author       = {Meikle, L. and Kwiatkowski, D. J. and others},
  title        = {{Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function}},
  journal      = {The Journal of neuroscience},
  year         = {2008},
  doi          = {10.1523/JNEUROSCI.0955-08.2008},
  note         = {PMID: 18495876},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record MEI2008) [Data set]. https://mtor-atlas.org/study/MEI2008/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_MEI2008,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record MEI2008},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/MEI2008/},
  doi          = {10.5281/zenodo.22059963}
}