Sestrins inhibit mTORC1 kinase activation through the GATOR complex

The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a sensor of different environmental conditions and regulator of cell growth, metabolism, and autophagy. mTORC1 is activated by Rag GTPases, working as RagA:RagB and RagC:RagD heterodimers. Rags control mTORC1 activity by tethering mTORC1 to the lysosomes where it is activated by Rheb GTPase. RagA:RagB, active in its GTP-bound form, is inhibited by GATOR1 complex, a GTPase-activating protein, and GATOR1 is in turn negatively regulated by GATOR2 complex.

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Parmigiani, A., et al. (2014). Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell reports. https://doi.org/10.1016/j.celrep.2014.10.019

@article{PAR2014,
  author       = {Parmigiani, A. and Budanov, A. V. and others},
  title        = {{Sestrins inhibit mTORC1 kinase activation through the GATOR complex}},
  journal      = {Cell reports},
  year         = {2014},
  doi          = {10.1016/j.celrep.2014.10.019},
  note         = {PMID: 25457612},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record PAR2014) [Data set]. https://mtor-atlas.org/study/PAR2014/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_PAR2014,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record PAR2014},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/PAR2014/},
  doi          = {10.5281/zenodo.22059963}
}