Sestrins inhibit mTORC1 kinase activation through the GATOR complex

Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV · 2014 · Cell reports · Atlas ID PAR2014

What this study shows

Sestrins inhibit mTORC1 activation through the GATOR2 complex.

Abstract

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The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a sensor of different environmental conditions and regulator of cell growth, metabolism, and autophagy. mTORC1 is activated by Rag GTPases, working as RagA:RagB and RagC:RagD heterodimers. Rags control mTORC1 activity by tethering mTORC1 to the lysosomes where it is activated by Rheb GTPase. RagA:RagB, active in its GTP-bound form, is inhibited by GATOR1 complex, a GTPase-activating protein, and GATOR1 is in turn negatively regulated by GATOR2 complex.

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At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Cell reports
Year	2014
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.celrep.2014.10.019 · PMID 25457612 · Free full text (PMC4303546)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Biochemical/genetic (Sestrins)
Target	Sestrins / GATOR / Rag / mTORC1
Model	Mammalian cells
Effect	Sestrins inhibit mTORC1 kinase activation through the GATOR complex

In the Atlas

Links in the pathway map

Supports GATOR2 inhibits GATOR1
Supports Sestrin2 inhibits GATOR2

Cite this paper

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Parmigiani, A., Nourbakhsh, A., Ding, B., Wang, W., Kim, Y. C., Akopiants, K., Guan, K. L., Karin, M., & Budanov, A. V. (2014). Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell reports. https://doi.org/10.1016/j.celrep.2014.10.019

@article{PAR2014,
  author       = {Parmigiani, A. and Nourbakhsh, A. and Ding, B. and Wang, W. and Kim, Y. C. and Akopiants, K. and Guan, K. L. and Karin, M. and Budanov, A. V.},
  title        = {{Sestrins inhibit mTORC1 kinase activation through the GATOR complex}},
  journal      = {Cell reports},
  year         = {2014},
  doi          = {10.1016/j.celrep.2014.10.019},
  note         = {PMID: 25457612},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record PAR2014) [Data set]. https://mtor-atlas.org/study/PAR2014/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_PAR2014,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record PAR2014},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/PAR2014/},
  doi          = {10.5281/zenodo.22059963}
}

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