Andrei V. Budanov
Helped identify the Sestrins as stress-induced proteins and was among the groups that showed they inhibit mTORC1 through the GATOR complex, a brake that protects against age-related disease
Ussher Assistant Professor, Biochemistry, Trinity College Dublin · Assistant Professor, VCU Massey Cancer Center · postdoc, Michael Karin lab, UC San Diego
Budanov Lab, Trinity College Dublin (Dublin, Ireland) ↗ ORCID0000-0002-7943-1000 ↗
Portrait: Trinity College Dublin
In flies (LEE2010, led by Jun Hee Lee in Michael Karin's lab), helped show loss of Sestrin lets TOR run unchecked, producing fat accumulation, mitochondrial dysfunction, muscle wasting, heart failure — reversible by inhibiting TOR or activating AMPK; established a TOR–Sestrin negative feedback loop. Follow-up (PAR2014): Sestrins interact with GATOR2 (also reported by the Sabatini lab), blocking mTORC1 recruitment to the lysosome — an AMPK-independent brake.
Traces back to his postdoc with Michael Karin (Sestrin1/2 as p53 targets activating AMPK to inhibit mTOR after DNA damage, 2008 Cell, BUD2008). Now at Trinity College Dublin.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2008 | M | p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling BUD2008 First author: p53 targets Sestrin1 and Sestrin2 activate AMPK and TSC2 to inhibit mTOR after DNA damage (cells and mice). |
| 2010 | A | Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies LEE2010 Loss of Sestrin in flies lets TOR run unchecked, causing fat/mitochondrial/muscle/heart pathology reversible by blocking TOR or activating AMPK. |
| 2014 | M | Sestrins inhibit mTORC1 kinase activation through the GATOR complex PAR2014 Sestrins block mTORC1 by binding GATOR2, preventing mTOR from reaching the lysosome. |
Co-authors in the Atlas 4
People with a profile here who share at least one study with Andrei V. Budanov.
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- Michael Karin 3 shared studies Cell biologist best known for discovering AP-1 and JNK signaling and the IKK-NF-kB inflammation pathway, whose lab also co-led the study of Sestrin as a feedback inhibitor of TOR.
- Anita Parmigiani Molecular biologist who worked in Andrei Budanov's lab at Virginia Commonwealth University on Sestrins, stress-induced proteins that hold back mTORC1
- Jun Hee Lee Physiologist at the University of Michigan who first showed in flies that Sestrin is a feedback brake on TOR that protects against age-related decline, and has since studied Sestrins as stress-induced regulators of mTORC1
- Kun-Liang Guan Showed how growth-factor and energy signals reach mTORC1 through TSC2 and Rheb, and, in parallel with the Sabatini lab, that the Rag GTPases carry the amino-acid signal. His lab also found that AMPK and mTORC1 control autophagy by phosphorylating the kinase ULK1 at different sites
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