LncRNA DLX6-AS1 promotes necroptosis through PI3K/AKT/mTOR signaling pathway in myocardial ischemia/reperfusion injury mice

Su Y, Mu L, Wang L, Li T, Zhang Q, Zhang Jun · 2026 · Scientific Reports · Atlas ID SU2026

What this study shows

LncRNA DLX6-AS1 activates PI3K/AKT/mTOR signaling to promote necroptosis in myocardial ischemia-reperfusion injury; inhibiting DLX6-AS1 suppresses necroptosis and protects cardiomyocytes.

Abstract

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Myocardial ischemia/reperfusion injury (MIRI) leads to life-threatening myocardial infarction. Necroptosis is involved in MIRI. DLX6-AS1 overexpression caused cell damage and necroptosis and increased the expression of PI3K, p-PI3K, AKT, p-AKT, mTOR and p-mTOR. DLX6-AS1 inhibition suppressed necroptosis and cell damage through the PI3K/AKT/mTOR signaling pathway. Myocardial ischemia-reperfusion injury induces necroptosis, and DLX6-AS1 promotes this process through the PI3K/AKT/mTOR signaling pathway.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse; Rat H9c2 cells); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Mouse; Rat H9c2 cells
Journal	Scientific Reports
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/s41598-026-50371-y · PMID 42601357 · Free full text (PMC13476243)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	DLX6-AS1 overexpression/inhibition
Target	PI3K/AKT/mTOR pathway; RIP1; RIP3; MLKL
Model	Mouse; Rat
Effect	DLX6-AS1 activates PI3K/AKT/mTOR, promoting necroptosis in cardiac I/R injury; knockdown is cardioprotective

In the Atlas

Cite this paper

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Su, Y., Mu, L., Wang, L., Li, T., Zhang, Q., & Zhang Jun (2026). LncRNA DLX6-AS1 promotes necroptosis through PI3K/AKT/mTOR signaling pathway in myocardial ischemia/reperfusion injury mice. Scientific Reports. https://doi.org/10.1038/s41598-026-50371-y

@article{SU2026,
  author       = {Su, Y. and Mu, L. and Wang, L. and Li, T. and Zhang, Q. and Zhang Jun},
  title        = {{LncRNA DLX6-AS1 promotes necroptosis through PI3K/AKT/mTOR signaling pathway in myocardial ischemia/reperfusion injury mice}},
  journal      = {Scientific Reports},
  year         = {2026},
  doi          = {10.1038/s41598-026-50371-y},
  note         = {PMID: 42601357},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SU2026) [Data set]. https://mtor-atlas.org/study/SU2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SU2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SU2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SU2026/},
  doi          = {10.5281/zenodo.22059963}
}

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