Rapamycin co-exposure fails to reduce cisplatin-induced damage in GC6-spg spermatogonial cell line.

Jibrin A, Mitchell RT, Lopes F · 2026 · Reproduction & Fertility · Atlas ID JIB2026

What this study shows

Rapamycin fails to protect spermatogonial stem cells from cisplatin-induced damage in vitro, indicating sex-specific or context-specific limits to rapamycin's cytoprotective role and suggesting male fertility preservation requires alternative strategies.

Abstract

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This study assessed whether rapamycin could protect male spermatogonial stem cells (GC6-spg line) from cisplatin-induced cytotoxicity, analogous to its protective role reported in female fertility preservation. Rapamycin co-exposure did not prevent cisplatin-induced cell loss or damage in this spermatogonial cell line, suggesting limited utility for male fertility preservation during cancer treatment.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: GC6-spg spermatogonial cell line) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	GC6-spg spermatogonial cell line
Journal	Reproduction & Fertility
Year	2026
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1530/RAF-26-0044 · PMID 42455795

Extracted findings

Intervention	Rapamycin
Target	mTOR inhibition; spermatogonial stem cell survival
Model	Human (cell line)
Effect	No protective effect – rapamycin does not rescue cisplatin-induced spermatogonial stem cell loss (negative result)

In the Atlas

Cite this paper

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Jibrin, A., Mitchell, R. T., & Lopes, F. (2026). Rapamycin co-exposure fails to reduce cisplatin-induced damage in GC6-spg spermatogonial cell line. Reproduction & Fertility. https://doi.org/10.1530/RAF-26-0044

@article{JIB2026,
  author       = {Jibrin, A. and Mitchell, R. T. and Lopes, F.},
  title        = {{Rapamycin co-exposure fails to reduce cisplatin-induced damage in GC6-spg spermatogonial cell line}},
  journal      = {Reproduction & Fertility},
  year         = {2026},
  doi          = {10.1530/RAF-26-0044},
  note         = {PMID: 42455795},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record JIB2026) [Data set]. https://mtor-atlas.org/study/JIB2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_JIB2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record JIB2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/JIB2026/},
  doi          = {10.5281/zenodo.22059963}
}