Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets.

Sills AM, Artavia JM, DeRosa BD, Ross CN, Salmon AB · 2018 · American Journal of Primatology · Atlas ID SIL2018

What this study shows

In middle-aged marmosets given daily rapamycin, 9 months of treatment produced only minor changes in cellular blood counts, so hematological side effects are not likely outcomes of long-term rapamycin in relatively healthy middle-aged animals. Trough blood concentrations of rapamycin were significantly lower in females than in males, yet both sexes changed little. At baseline, males and females differed little in morphology or in markers of blood cell counts, metabolism and inflammation. Boundary: healthy middle-aged marmosets, 9 months, hematology and clinical laboratory markers only; it says nothing about efficacy or lifespan, and the abstract does not give the dose or group sizes.

Abstract

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Interventions to extend lifespan and improve health with increasing age would have significant impact on a growing aged population. There are now several pharmaceutical interventions that extend lifespan in laboratory rodent models with rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR) being the most well studied. In this study, we report on the hematological effects in a cohort of middle-aged common marmosets (Callithrix jacchus) that were enrolled in a study to test the effects of daily rapamycin treatment on aging in this species.

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At a glance

Evidence type	A Animal model Marked A because it is an animal study reporting a negative or null result (model: Middle-aged common marmosets (Callithrix jacchus), daily oral rapamycin, hematology and clinical laboratory markers, sex as a factor); a well-designed null result is still evidence, and the code names the system studied, not the importance.
Study type	4 - Animal Study
Model system	Middle-aged common marmosets (Callithrix jacchus), daily oral rapamycin, hematology and clinical laboratory markers, sex as a factor
Journal	American Journal of Primatology
Year	2018
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1002/ajp.22927 · PMID 30311681 · Free full text (PMC6415526)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Daily oral rapamycin for 9 months
Target	Hematological and clinical laboratory markers
Model	Common marmoset (Callithrix jacchus)
Effect	Only minor changes in blood counts after 9 months; lower trough rapamycin in females than males

In the Atlas

Cite this paper

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Sills, A. M., Artavia, J. M., DeRosa, B. D., Ross, C. N., & Salmon, A. B. (2018). Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets. American Journal of Primatology. https://doi.org/10.1002/ajp.22927

@article{SIL2018,
  author       = {Sills, A. M. and Artavia, J. M. and DeRosa, B. D. and Ross, C. N. and Salmon, A. B.},
  title        = {{Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets}},
  journal      = {American Journal of Primatology},
  year         = {2018},
  doi          = {10.1002/ajp.22927},
  note         = {PMID: 30311681},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SIL2018) [Data set]. https://mtor-atlas.org/study/SIL2018/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SIL2018,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SIL2018},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SIL2018/},
  doi          = {10.5281/zenodo.22059963}
}

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