mTOR Signaling in Growth, Metabolism, and Disease

The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors. Extensive research over the past two decades has established a central role for mTOR in regulating many fundamental cell processes, from protein synthesis to autophagy, and deregulated mTOR signaling is implicated in the progression of cancer and diabetes, as well as the aging process. Here, we review recent advances in our understanding of mTOR function, regulation, and importance in mammalian physiology.

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Saxton, R. A., & Sabatini, D. M. (2017). mTOR Signaling in Growth, Metabolism, and Disease. Cell. https://doi.org/10.1016/j.cell.2017.02.004

@article{SAX2017,
  author       = {Saxton, R. A. and Sabatini, D. M.},
  title        = {{mTOR Signaling in Growth, Metabolism, and Disease}},
  journal      = {Cell},
  year         = {2017},
  doi          = {10.1016/j.cell.2017.02.004},
  note         = {PMID: 28283069},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SAX2017) [Data set]. https://mtor-atlas.org/study/SAX2017/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SAX2017,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SAX2017},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SAX2017/},
  doi          = {10.5281/zenodo.22059963}
}