mTOR Signaling in Growth, Metabolism, and Disease

Saxton RA, Sabatini DM · 2017 · Cell · Atlas ID SAX2017

What this study shows

Comprehensive synthesis of mTORC1/mTORC2 signaling, growth regulation, metabolism, and disease relevance.

Abstract

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The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors. Extensive research over the past two decades has established a central role for mTOR in regulating many fundamental cell processes, from protein synthesis to autophagy, and deregulated mTOR signaling is implicated in the progression of cancer and diabetes, as well as the aging process. Here, we review recent advances in our understanding of mTOR function, regulation, and importance in mammalian physiology.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review article
Journal	Cell
Year	2017
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.cell.2017.02.004 · PMID 28283069 · Free full text (PMC5394987)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	mTORC1 / mTORC2
Model	Review
Effect	Comprehensive review of mTOR in growth, metabolism and autophagy; deregulation in cancer, diabetes and aging

In the Atlas

Cite this paper

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Saxton, R. A., & Sabatini, D. M. (2017). mTOR Signaling in Growth, Metabolism, and Disease. Cell. https://doi.org/10.1016/j.cell.2017.02.004

@article{SAX2017,
  author       = {Saxton, R. A. and Sabatini, D. M.},
  title        = {{mTOR Signaling in Growth, Metabolism, and Disease}},
  journal      = {Cell},
  year         = {2017},
  doi          = {10.1016/j.cell.2017.02.004},
  note         = {PMID: 28283069},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SAX2017) [Data set]. https://mtor-atlas.org/study/SAX2017/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SAX2017,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SAX2017},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SAX2017/},
  doi          = {10.5281/zenodo.22059963}
}

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