Comprehensive synthesis of mTORC1/mTORC2 signaling, growth regulation, metabolism, and disease relevance.
| Evidence tier | D Mechanistic / in vitro / review |
| Study type | Narrative Review |
| Model system | Review article |
| Journal | Cell |
| Year | 2017 |
| Peer reviewed | Yes |
| Source | DOI 10.1016/j.cell.2017.02.004 · PMID 28283069 · Free full text (PMC5394987) |
The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors. Extensive research over the past two decades has established a central role for mTOR in regulating many fundamental cell processes, from protein synthesis to autophagy, and deregulated mTOR signaling is implicated in the progression of cancer and diabetes, as well as the aging process. Here, we review recent advances in our understanding of mTOR function, regulation, and importance in mammalian physiology. We also highlight how the mTOR signaling network contributes to human disease and discuss the current and future prospects for therapeutically targeting mTOR in the clinic.
| Intervention | Not applicable (review) |
| Target | mTORC1 / mTORC2 |
| Model | Review |
| Effect | Comprehensive review of mTOR in growth, metabolism and autophagy; deregulation in cancer, diabetes and aging |