Pregnane X receptor-mediated liver growth: a controlled clinical trial in healthy volunteers and identification of the role of AKT-MTOR pathway in mouse.

Pregnane X receptor (PXR) is a master xenobiotic nuclear receptor. Activation of PXR has been linked to liver growth in mice, usually via interaction with YAP, but this adaptive response had not been observed in humans. The authors investigated the effect of the human PXR agonist rifampicin on liver size in a controlled clinical trial in healthy volunteers. One-week rifampicin treatment caused a 2.7% mean increase in liver volume-to-body weight ratio without affecting liver fat content (n=16).

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Lassila, P., et al. (2026). Pregnane X receptor-mediated liver growth: a controlled clinical trial in healthy volunteers and identification of the role of AKT-MTOR pathway in mouse. Archives of Toxicology. https://doi.org/10.1007/s00204-026-04526-5

@article{LASSILA2026,
  author       = {Lassila, P. and Karpale, M. and Kummu, O. and others},
  title        = {{Pregnane X receptor-mediated liver growth: a controlled clinical trial in healthy volunteers and identification of the role of AKT-MTOR pathway in mouse}},
  journal      = {Archives of Toxicology},
  year         = {2026},
  doi          = {10.1007/s00204-026-04526-5},
}

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The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record LASSILA2026) [Data set]. https://mtor-atlas.org/study/LASSILA2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LASSILA2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LASSILA2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LASSILA2026/},
  doi          = {10.5281/zenodo.22059963}
}