Microbiota-associated kynurenic acid drives PD-1 blockade resistance through an ITGA2-mTOR-CTSV axis in gastric cancer.

The tumor microbiota critically shapes responses to immunotherapy; however, the mechanisms by which specific microbial species drive immune checkpoint blockade (ICB) resistance in gastric cancer (GC) remain poorly defined. Bacterial enrichment was assessed in ICB-unresponsive GC tissues from patients and multiple preclinical models. Orthotopic, subcutaneous, and germ-free mono-colonized mouse models were employed to evaluate the impact on antitumor immunity and PD-1 blockade efficacy.

Read the full abstract on PubMed →

Ren, Y., et al. (2026). Microbiota-associated kynurenic acid drives PD-1 blockade resistance through an ITGA2-mTOR-CTSV axis in gastric cancer. Journal for immunotherapy of cancer. https://doi.org/10.1136/jitc-2026-015172

@article{REN2026,
  author       = {Ren, Y. and Yu, X. and Jiang, J. and Luo, J. and Zhao, C. and others},
  title        = {{Microbiota-associated kynurenic acid drives PD-1 blockade resistance through an ITGA2-mTOR-CTSV axis in gastric cancer}},
  journal      = {Journal for immunotherapy of cancer},
  year         = {2026},
  doi          = {10.1136/jitc-2026-015172},
  note         = {PMID: 42562425},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record REN2026) [Data set]. https://mtor-atlas.org/study/REN2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_REN2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record REN2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/REN2026/},
  doi          = {10.5281/zenodo.22059963}
}