Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice

Strong R, Miller RA, Cheng CJ, Nelson JF, Gelfond J, Harrison DE et al. · 2022 · Aging Cell · Atlas ID STR2022

What this study shows

NIA Interventions Testing Program C2017 cohort. In MALE mice, rapamycin plus acarbose started at 9 months produced a longer lifespan than either of the two prior ITP cohorts treated with rapamycin alone, suggesting the combination is more potent than its components used separately. In FEMALES the combination was neither better nor worse than rapamycin alone, which the authors relate to the limited survival benefit acarbose alone had shown in earlier female cohorts. Captopril gave a small but significant lifespan increase in females (4-5%). CAVEAT (important for how this is cited): the rapamycin-only comparison is HISTORICAL, against prior cohorts, not a concurrent rapamycin-only arm in the same experiment, so 'more potent than either component' is the authors' suggestion rather than a within-experiment randomised comparison.

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Genetically heterogeneous UM-HET3 mice, three test sites (ITP C2017 cohort)); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Genetically heterogeneous UM-HET3 mice, three test sites (ITP C2017 cohort)
Journal	Aging Cell
Year	2022
Peer reviewed	—
Record last updated	2026-08-22
Source	DOI 10.1111/acel.13724 · PMID 36179270 · Free full text (PMC9741502)

Extracted findings

Intervention	Rapamycin + acarbose combination; captopril; (R/S)-1,3-butanediol; leucine; PB125; sulindac; syringaresinol
Target	mTORC1 (rapamycin); alpha-glucosidase / glucose absorption (acarbose)
Model	Mouse
Effect	Rapamycin + acarbose from 9 months outlived prior rapamycin-only cohorts in males; no added benefit over rapamycin alone in females

In the Atlas

Cite this paper

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Strong, R., et al. (2022). Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice. Aging Cell. https://doi.org/10.1111/acel.13724

@article{STR2022,
  author       = {Strong, R. and Miller, R. A. and Cheng, C. J. and Nelson, J. F. and Gelfond, J. and Harrison, D. E. and others},
  title        = {{Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice}},
  journal      = {Aging Cell},
  year         = {2022},
  doi          = {10.1111/acel.13724},
  note         = {PMID: 36179270},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record STR2022) [Data set]. https://mtor-atlas.org/study/STR2022/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_STR2022,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record STR2022},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/STR2022/},
  doi          = {10.5281/zenodo.22059963}
}