Notoginsenoside R1 Alleviates Acetaminophen-Induced Liver Injury via MAPK/mTOR-Mediated Autophagy.

Li S, Liu Z, Pan G, Li S, Lv G, Tang S, Li J, Li Q, Wu M, Yuan G, Yu S, Ouyang G · 2026 · The American Journal of Chinese Medicine · Atlas ID LIS2026

What this study shows

Notoginsenoside R1 alleviates acetaminophen-induced acute liver injury by activating protective autophagy through MAPK/mTOR pathway modulation, reducing hepatocyte death and oxidative damage.

Abstract

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Notoginsenoside R1 (NGR1), a bioactive saponin from Panax notoginseng, was investigated in acetaminophen-induced acute liver injury (AILI). NGR1 treatment activated autophagy via modulation of the MAPK/mTOR pathway, reducing hepatocyte apoptosis and oxidative stress, and attenuating liver injury in mouse models and hepatocyte cultures.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Mouse
Journal	The American Journal of Chinese Medicine
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1142/S0192415X26500576 · PMID 42459050

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Notoginsenoside R1
Target	MAPK/mTOR pathway; autophagy
Model	Mouse
Effect	NGR1 suppresses mTOR to activate autophagy, reducing APAP-induced hepatocyte apoptosis and liver injury

In the Atlas

Cite this paper

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Li, S., Liu, Z., Pan, G., Li, S., Lv, G., Tang, S., Li, J., Li, Q., Wu, M., Yuan, G., Yu, S., & Ouyang, G. (2026). Notoginsenoside R1 Alleviates Acetaminophen-Induced Liver Injury via MAPK/mTOR-Mediated Autophagy. The American Journal of Chinese Medicine. https://doi.org/10.1142/S0192415X26500576

@article{LIS2026,
  author       = {Li, S. and Liu, Z. and Pan, G. and Li, S. and Lv, G. and Tang, S. and Li, J. and Li, Q. and Wu, M. and Yuan, G. and Yu, S. and Ouyang, G.},
  title        = {{Notoginsenoside R1 Alleviates Acetaminophen-Induced Liver Injury via MAPK/mTOR-Mediated Autophagy}},
  journal      = {The American Journal of Chinese Medicine},
  year         = {2026},
  doi          = {10.1142/S0192415X26500576},
  note         = {PMID: 42459050},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record LIS2026) [Data set]. https://mtor-atlas.org/study/LIS2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LIS2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LIS2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LIS2026/},
  doi          = {10.5281/zenodo.22059963}
}

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