Notoginsenoside R1 Alleviates Acetaminophen-Induced Liver Injury via MAPK/mTOR-Mediated Autophagy.

Notoginsenoside R1 (NGR1), a bioactive saponin from Panax notoginseng, was investigated in acetaminophen-induced acute liver injury (AILI). NGR1 treatment activated autophagy via modulation of the MAPK/mTOR pathway, reducing hepatocyte apoptosis and oxidative stress, and attenuating liver injury in mouse models and hepatocyte cultures.

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Li, S., Liu, Z., Pan, G., Li, Y., & Lv, K. (2026). Notoginsenoside R1 Alleviates Acetaminophen-Induced Liver Injury via MAPK/mTOR-Mediated Autophagy. The American Journal of Chinese Medicine. https://doi.org/10.1142/S0192415X26500576

@article{LIS2026,
  author       = {Li, S. and Liu, Z. and Pan, G. and Li, Y. and Lv, K.},
  title        = {{Notoginsenoside R1 Alleviates Acetaminophen-Induced Liver Injury via MAPK/mTOR-Mediated Autophagy}},
  journal      = {The American Journal of Chinese Medicine},
  year         = {2026},
  doi          = {10.1142/S0192415X26500576},
  note         = {PMID: 42459050},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record LIS2026) [Data set]. https://mtor-atlas.org/study/LIS2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LIS2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LIS2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LIS2026/},
  doi          = {10.5281/zenodo.22059963}
}