TORC1 and PKA activity towards ribosome biogenesis oscillates in synchrony with the budding yeast cell cycle

Guerra P, Milias-Argeitis A et al. · 2022 · Journal of Cell Science · Atlas ID GUE2022

What this study shows

Tracking the localisation of two TORC1 and PKA targets by time-lapse microscopy in hundreds of yeast cells shows that TORC1/PKA activity towards ribosome biogenesis rises and falls in step with the cell cycle even when outside conditions stay constant; mutations in upstream regulators suggest internal metabolic signals partly drive the oscillation.

Abstract

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Recent studies have revealed that the growth rate of budding yeast and mammalian cells varies during the cell cycle. By linking a multitude of signals to cell growth, the highly conserved target of rapamycin complex 1 (TORC1) and protein kinase A (PKA) pathways are prime candidates for mediating the dynamic coupling between growth and division. However, measurements of TORC1 and PKA activity during the cell cycle are still lacking.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Budding yeast (Saccharomyces cerevisiae), time-lapse single-cell microscopy) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Budding yeast (Saccharomyces cerevisiae), time-lapse single-cell microscopy
Journal	Journal of Cell Science
Year	2022
Peer reviewed	Yes
Record last updated	2026-09-23
Source	DOI 10.1242/jcs.260378 · PMID 35975715 · Free full text (PMC9658999)

Extracted findings

Intervention	None (constant conditions); upstream regulator mutants
Target	TORC1 / PKA
Model	Yeast
Effect	TORC1/PKA output to ribosome biogenesis oscillates with the yeast cell cycle under constant conditions

Cite this paper

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Guerra, P., et al. (2022). TORC1 and PKA activity towards ribosome biogenesis oscillates in synchrony with the budding yeast cell cycle. Journal of Cell Science. https://doi.org/10.1242/jcs.260378

@article{GUE2022,
  author       = {Guerra, P. and Milias-Argeitis, A. and others},
  title        = {{TORC1 and PKA activity towards ribosome biogenesis oscillates in synchrony with the budding yeast cell cycle}},
  journal      = {Journal of Cell Science},
  year         = {2022},
  doi          = {10.1242/jcs.260378},
  note         = {PMID: 35975715},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record GUE2022) [Data set]. https://mtor-atlas.org/study/GUE2022/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GUE2022,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GUE2022},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GUE2022/},
  doi          = {10.5281/zenodo.22059963}
}