TORC1 and PKA activity towards ribosome biogenesis oscillates in synchrony with the budding yeast cell cycle
What this study shows
Tracking the localisation of two TORC1 and PKA targets by time-lapse microscopy in hundreds of yeast cells shows that TORC1/PKA activity towards ribosome biogenesis rises and falls in step with the cell cycle even when outside conditions stay constant; mutations in upstream regulators suggest internal metabolic signals partly drive the oscillation.
Abstract
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Recent studies have revealed that the growth rate of budding yeast and mammalian cells varies during the cell cycle. By linking a multitude of signals to cell growth, the highly conserved target of rapamycin complex 1 (TORC1) and protein kinase A (PKA) pathways are prime candidates for mediating the dynamic coupling between growth and division. However, measurements of TORC1 and PKA activity during the cell cycle are still lacking.
Read the full abstract on PubMed →At a glance
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| Evidence type | M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Budding yeast (Saccharomyces cerevisiae), time-lapse single-cell microscopy) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is. |
| Study type | 5 - Mechanistic / In Vitro |
| Model system | Budding yeast (Saccharomyces cerevisiae), time-lapse single-cell microscopy |
| Journal | Journal of Cell Science |
| Year | 2022 |
| Peer reviewed | Yes |
| Record last updated | 2026-10-01 |
| Source | DOI 10.1242/jcs.260378 · PMID 35975715 · Free full text (PMC9658999) |
Where this study fits
How this study connects to the pathway map, open questions, people and other studies in the Atlas.
Pathway relations
Supports
mTORC1 activates Ribosome biogenesisStrongest evidence: M (Molecular — cells, biochemistry, structure) · emerging, few independent studies · Status: Proposed
plausible in people, not shown directly
Both polymerase branches are in the corpus as of 7 November 2026, and both are indirect: neither paper could show mTOR phosphorylating its target. MAY2004 writes that mTOR activates TIF-IA directly or indirectly and reports that…
People in the Atlas
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Systems biologist who tracked TORC1 and PKA signalling in single yeast cells and showed that their growth signals rise and fall with the cell cycle
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Follows TORC1 activity through the cell cycle in single yeast cells and builds light-controlled tools to perturb it
More: 3 other authors
No profile yet: Vuillemenot LPE, van Oppen YB, Been M
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Topics
Extracted findings
These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.
| Intervention | None (constant conditions); upstream regulator mutants |
| Target | TORC1 / PKA |
| Model | Yeast |
| Effect | TORC1/PKA output to ribosome biogenesis oscillates with the yeast cell cycle under constant conditions |
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