SGK1

Gene/Protein · 2 studies in the Atlas

Serum- and glucocorticoid-regulated kinase 1; a second major AGC kinase phosphorylated and activated by mTORC2 at its hydrophobic motif. Controls ion transport, cell survival, and glucose metabolism. mTORC2→SGK1 signaling is a key output branch of mTORC2 parallel to the mTORC2→Akt axis.

Another kinase mTORC2 switches on. A signaling protein activated by mTORC2 (the second mTOR complex). It's a lesser-known cousin of Akt and helps control things like salt/water balance in cells, cell survival, and how cells handle sugar.

Shares substrate motifs with Akt (e.g. NDRG1, used as the standard mTORC2 readout because it is Akt-independent).

TL;DR. SGK1 appears in 2 curated studies in Oliver's mTOR Atlas: 2 at the molecular level (cells, biochemistry, structure). No study in people is recorded for it in the Atlas yet. It has 1 interaction in the curated pathway model.

In the pathway model

1 interaction in the curated mTOR pathway model. Each row is a claim with the evidence behind it; the evidence code is the kind of study, not its quality.

Interaction	Mechanism	Evidence	Studies
mTORC2 activates SGK1 mechanism: phosphorylation · this link in full · on the map table	SGK1 is a second target of mTORC2 alongside Akt, and it shares some of Akt's jobs. SGK1 is a second mTORC2 substrate alongside Akt, and it carries some of the functions usually credited to Akt. SGK1 is a second mTORC2 substrate alongside Akt, and it carries some of the functions usually credited to Akt. Holds under: Single-study edge in this corpus. plausible in people, not shown directly · emerging, few independent studies	M	GAR2008

Evidence at a glance

Evidence	What it means	Studies
M	Molecular — cells, biochemistry, structure	2

No direct human evidence in the Atlas for this entity yet — everything below rests on animal or molecular work.

Studies

Year	Evidence	Study
2009	M	Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR) GAR2009 Ku-0063794 is a specific ATP-competitive mTOR inhibitor blocking mTORC1 and mTORC2.
2008	M	mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1) GAR2008 mTORC2 controls hydrophobic-motif phosphorylation and activity of SGK1 in addition to Akt.

Related entities

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Barton, O. (2026). SGK1 [Entity page]. In Oliver's mTOR Atlas [Data set]. https://mtor-atlas.org/gene/sgk1/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_gene_sgk1,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}: SGK1},
  howpublished = {Entity page in a data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/gene/sgk1/},
  doi          = {10.5281/zenodo.22059963}
}

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