mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation

Morita M, Sonenberg N et al. · 2013 · Cell metabolism · Atlas ID MOR2013

What this study shows

mTORC1 controls mitochondrial biogenesis and activity through 4E-BP-dependent translation.

Abstract

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mRNA translation is thought to be the most energy-consuming process in the cell. Translation and energy metabolism are dysregulated in a variety of diseases including cancer, diabetes, and heart disease. However, the mechanisms that coordinate translation and energy metabolism in mammals remain largely unknown. The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) stimulates mRNA translation and other anabolic processes.

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At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Cell metabolism
Year	2013
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1016/j.cmet.2013.10.001 · PMID 24206664

Extracted findings

Intervention	Genetic/pharmacologic (mTORC1 / 4E-BP)
Target	mTORC1 / 4E-BP
Model	Mammalian cells
Effect	mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translation

Cite this paper

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Morita, M., et al. (2013). mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell metabolism. https://doi.org/10.1016/j.cmet.2013.10.001

@article{MOR2013,
  author       = {Morita, M. and Sonenberg, N. and others},
  title        = {{mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation}},
  journal      = {Cell metabolism},
  year         = {2013},
  doi          = {10.1016/j.cmet.2013.10.001},
  note         = {PMID: 24206664},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record MOR2013) [Data set]. https://mtor-atlas.org/study/MOR2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_MOR2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record MOR2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/MOR2013/},
  doi          = {10.5281/zenodo.22059963}
}