mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation

Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, …, Sonenberg N · 2013 · Cell metabolism · Atlas ID MOR2013

What this study shows

mTORC1 controls mitochondrial biogenesis and activity through 4E-BP-dependent translation.

Abstract

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mRNA translation is thought to be the most energy-consuming process in the cell. Translation and energy metabolism are dysregulated in a variety of diseases including cancer, diabetes, and heart disease. However, the mechanisms that coordinate translation and energy metabolism in mammals remain largely unknown. The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) stimulates mRNA translation and other anabolic processes.

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At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Cell metabolism
Year	2013
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.cmet.2013.10.001 · PMID 24206664

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic/pharmacologic (mTORC1 / 4E-BP)
Target	mTORC1 / 4E-BP
Model	Mammalian cells
Effect	mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translation

In the Atlas

Links in the pathway map

Supports 4E-BP1 context-dependent Mitochondrial biogenesis
Supports mTORC1 activates Mitochondrial biogenesis
Supports mTORC1 activates Oxidative phosphorylation

Cite this paper

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Morita, M., Gravel, S. P., Chénard, V., Sikström, K., Zheng, L., Alain, T., Gandin, V., Avizonis, D., Arguello, M., Zakaria, C., McLaughlan, S., Nouet, Y., Pause, A., Pollak, M., Gottlieb, E., Larsson, O., St-Pierre, J., Topisirovic, I., & Sonenberg, N. (2013). mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell metabolism. https://doi.org/10.1016/j.cmet.2013.10.001

@article{MOR2013,
  author       = {Morita, M. and Gravel, S. P. and Chénard, V. and Sikström, K. and Zheng, L. and Alain, T. and Gandin, V. and Avizonis, D. and Arguello, M. and Zakaria, C. and McLaughlan, S. and Nouet, Y. and Pause, A. and Pollak, M. and Gottlieb, E. and Larsson, O. and St-Pierre, J. and Topisirovic, I. and Sonenberg, N.},
  title        = {{mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation}},
  journal      = {Cell metabolism},
  year         = {2013},
  doi          = {10.1016/j.cmet.2013.10.001},
  note         = {PMID: 24206664},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record MOR2013) [Data set]. https://mtor-atlas.org/study/MOR2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_MOR2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record MOR2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/MOR2013/},
  doi          = {10.5281/zenodo.22059963}
}

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