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Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation.

Lv N, Tang Y, Zhang W, Zhang S, Zhang M · 2026 · Cell Death and Differentiation · Atlas ID LV2026

What this study shows

Age-driven loss of Lamtor5, a key lysosomal mTOR activation complex subunit, drives macrophage immunosenescence and systemic aging phenotypes in mice by unleashing cGAS-STING paracrine inflammation; Lamtor5 restoration in aged mice reverses these phenotypes.

Abstract

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Lamtor5 (late endosomal/lysosomal adapter, MAPK and mTOR activator 5) was identified as an age-dependent factor controlling innate immune cell function. Age-associated Lamtor5 decline impairs mTOR-dependent macrophage signaling, triggering cGAS-mediated paracrine inflammatory senescence. Restoring Lamtor5 in aged mice rescued immunosenescence and attenuated systemic aging phenotypes.

Read the full abstract on PubMed →

At a glance

Evidence type A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type4 - Animal Study
Model systemMouse
JournalCell Death and Differentiation
Year2026
Peer reviewedYes
Record last updated2026-07-29
SourceDOI 10.1038/s41418-026-01823-5 · PMID 42463581

Extracted findings

InterventionLamtor5 overexpression / restoration
TargetLamtor5 / mTORC1 Ragulator complex / cGAS-STING
ModelMouse
EffectDecline of Lamtor5 reduces mTOR activity in aging macrophages, promoting immunosenescence; Lamtor5 restoration reverses aging phenotypes

In the Atlas

Related topics

mTORSAMTORcGAS-STING pathway

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Cite this paper

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Lv, N., Tang, Y., Zhang, W., Zhang, S., & Zhang, M. (2026). Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation. Cell Death and Differentiation. https://doi.org/10.1038/s41418-026-01823-5

@article{LV2026,
  author       = {Lv, N. and Tang, Y. and Zhang, W. and Zhang, S. and Zhang, M.},
  title        = {{Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation}},
  journal      = {Cell Death and Differentiation},
  year         = {2026},
  doi          = {10.1038/s41418-026-01823-5},
  note         = {PMID: 42463581},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record LV2026) [Data set]. https://mtor-atlas.org/study/LV2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LV2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LV2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LV2026/},
  doi          = {10.5281/zenodo.22059963}
}