Oliver's mTOR Atlas Evidence Platform
Reading level
Mode

Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation.

Lv N, Tang Y, Zhang W, Zhang Q, Zhang H, Gao H, Cui S, Krasny S, Shi L · 2026 · Cell Death and Differentiation · Atlas ID LV2026

What this study shows

Age-driven loss of Lamtor5, a key lysosomal mTOR activation complex subunit, drives macrophage immunosenescence and systemic aging phenotypes in mice by unleashing cGAS-STING paracrine inflammation; restoring Lamtor5 in aged mice rescued immunosenescence and attenuated systemic ageing phenotypes.

Abstract

ShowHide

Lamtor5 (late endosomal/lysosomal adapter, MAPK and mTOR activator 5) was identified as an age-dependent factor controlling innate immune cell function. Age-associated Lamtor5 decline impairs mTOR-dependent macrophage signaling, triggering cGAS-mediated paracrine inflammatory senescence. Restoring Lamtor5 in aged mice rescued immunosenescence and attenuated systemic aging phenotypes.

Read the full abstract on PubMed →

At a glance

Evidence type A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type4 - Animal Study
Model systemMouse
JournalCell Death and Differentiation
Year2026
Peer reviewedYes
Record last updated2026-07-29
SourceDOI 10.1038/s41418-026-01823-5 · PMID 42463581

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

InterventionLamtor5 overexpression / restoration
TargetLamtor5 / mTORC1 Ragulator complex / cGAS-STING
ModelMouse
EffectDecline of Lamtor5 reduces mTOR activity in aging macrophages, promoting immunosenescence; Lamtor5 restoration reverses aging phenotypes

In the Atlas

Related topics

mTORcGAS-STING pathway

Links in the pathway map

Open questions that cite this study

Cite this paper

ShowHide 
Lv, N., Tang, Y., Zhang, W., Zhang, Q., Zhang, H., Gao, H., Cui, S., Krasny, S., & Shi, L. (2026). Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation. Cell Death and Differentiation. https://doi.org/10.1038/s41418-026-01823-5

@article{LV2026,
  author       = {Lv, N. and Tang, Y. and Zhang, W. and Zhang, Q. and Zhang, H. and Gao, H. and Cui, S. and Krasny, S. and Shi, L.},
  title        = {{Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation}},
  journal      = {Cell Death and Differentiation},
  year         = {2026},
  doi          = {10.1038/s41418-026-01823-5},
  note         = {PMID: 42463581},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record LV2026) [Data set]. https://mtor-atlas.org/study/LV2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LV2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LV2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LV2026/},
  doi          = {10.5281/zenodo.22059963}
}
Was this page useful?