Oliver's mTOR Atlas Evidence Platform
Reading level
Mode

mTOR signaling in aging: from causality to geroprotective interventions and hallmark-level outcomes

Bobok N · 2026 · Aging (Albany NY) · Atlas ID BOB2026

What this study shows

Frames mTOR as a dynamic, context-dependent signaling hub integrating nutrient sensing, proteostasis, autophagy and stress adaptation across the hallmarks of aging; surveys geroprotective interventions (autophagy activation, dietary restriction, exercise, senotherapeutics) that partly converge on mTOR signaling. Causal evidence for mTOR in lifespan regulation is strong in model organisms; human data remain associative but biologically consistent.

Abstract

ShowHide

The mechanistic target of rapamycin (mTOR) pathway is an important integrator of processes involved in aging and longevity, coordinating nutrient sensing, metabolic adaptation, and cellular stress responses. This review presents a three-section framework in which mTOR functions as a dynamic signaling hub coordinating multiple biological processes underlying the aging process.

Read the full abstract on PubMed →

At a glance

Evidence type R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study typeNarrative Review
Model systemNarrative review synthesis (model organisms + human associative data)
JournalAging (Albany NY)
Year2026
Peer reviewedYes
Record last updated2026-09-23
SourceDOI 10.18632/aging.206423 · PMID 42765942

Cite this paper

ShowHide 
Bobok, N. (2026). mTOR signaling in aging: from causality to geroprotective interventions and hallmark-level outcomes. Aging (Albany NY). https://doi.org/10.18632/aging.206423

@article{BOB2026,
  author       = {Bobok, N.},
  title        = {{mTOR signaling in aging: from causality to geroprotective interventions and hallmark-level outcomes}},
  journal      = {Aging (Albany NY)},
  year         = {2026},
  doi          = {10.18632/aging.206423},
  note         = {PMID: 42765942},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record BOB2026) [Data set]. https://mtor-atlas.org/study/BOB2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BOB2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BOB2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BOB2026/},
  doi          = {10.5281/zenodo.22059963}
}