Oliver's mTOR Atlas Evidence Platform
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mTOR signaling in aging: from causality to geroprotective interventions and hallmark-level outcomes

Bobok N · 2026 · Aging · Atlas ID BOB2026

What this study shows

Frames mTOR as a dynamic, context-dependent signaling hub integrating nutrient sensing, proteostasis, autophagy and stress adaptation across the hallmarks of aging; surveys geroprotective interventions (autophagy activation, dietary restriction, exercise, senotherapeutics) that partly converge on mTOR signaling. Causal evidence for mTOR in lifespan regulation is strong in model organisms; human data remain associative but biologically consistent.

Abstract

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The mechanistic target of rapamycin (mTOR) pathway is an important integrator of processes involved in aging and longevity, coordinating nutrient sensing, metabolic adaptation, and cellular stress responses. This review presents a three-section framework in which mTOR functions as a dynamic signaling hub coordinating multiple biological processes underlying the aging process.

Read the full abstract on PubMed →

At a glance

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Evidence type R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study typeNarrative Review
Model systemNarrative review synthesis (model organisms + human associative data)
JournalAging
Year2026
Peer reviewedYes
Record last updated2026-10-01
SourceDOI 10.18632/aging.206423 · PMID 42765942

Where this study fits

How this study connects to the pathway map, open questions, people and other studies in the Atlas.

People in the Atlas

  • Natalia Bobok first author · 1 study in the Atlas

    Physician-scientist and founder of a Swiss longevity/skincare company; author of a 2026 review situating mTOR as an integrative signaling hub across the hallmarks of aging

Related studies

More related studies

All 125 studies on mTOR

Topics

LongevitymTOR

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Interventionnone (narrative review)
TargetmTORC1 / mTORC2 signalling across hallmarks of ageing
ModelModel organisms and human associative data (review)
EffectArgues mTOR is a context-dependent hub in ageing, with causal evidence in model organisms and associative evidence in humans.

Cite this paper

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Bobok, N. (2026). mTOR signaling in aging: from causality to geroprotective interventions and hallmark-level outcomes. Aging. https://doi.org/10.18632/aging.206423

@article{BOB2026,
  author       = {Bobok, N.},
  title        = {{mTOR signaling in aging: from causality to geroprotective interventions and hallmark-level outcomes}},
  journal      = {Aging},
  year         = {2026},
  doi          = {10.18632/aging.206423},
  note         = {PMID: 42765942},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record BOB2026) [Data set]. https://mtor-atlas.org/study/BOB2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BOB2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BOB2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BOB2026/},
  doi          = {10.5281/zenodo.22059963}
}
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