Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

Flux through metabolic pathways is inherently sensitive to the levels of specific substrates and products, but cellular metabolism is also managed by integrated control mechanisms that sense the nutrient and energy status of a cell or organism. The mechanistic target of rapamycin complex 1 (mTORC1), a protein kinase complex ubiquitous to eukaryotic cells, has emerged as a critical signalling node that links nutrient sensing to the coordinated regulation of cellular metabolism.

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Dibble, C. C., et al. (2013). Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nature cell biology. https://doi.org/10.1038/ncb2763

@article{DIB2013,
  author       = {Dibble, C. C. and Manning, B. D. and others},
  title        = {{Signal integration by mTORC1 coordinates nutrient input with biosynthetic output}},
  journal      = {Nature cell biology},
  year         = {2013},
  doi          = {10.1038/ncb2763},
  note         = {PMID: 23728461},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record DIB2013) [Data set]. https://mtor-atlas.org/study/DIB2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DIB2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DIB2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DIB2013/},
  doi          = {10.5281/zenodo.22059963}
}