Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

Dibble CC, Manning BD · 2013 · Nature cell biology · Atlas ID DIB2013

What this study shows

Review: mTORC1 integrates nutrient input with biosynthetic output.

Abstract

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Flux through metabolic pathways is inherently sensitive to the levels of specific substrates and products, but cellular metabolism is also managed by integrated control mechanisms that sense the nutrient and energy status of a cell or organism. The mechanistic target of rapamycin complex 1 (mTORC1), a protein kinase complex ubiquitous to eukaryotic cells, has emerged as a critical signalling node that links nutrient sensing to the coordinated regulation of cellular metabolism.

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At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Nature cell biology
Year	2013
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/ncb2763 · PMID 23728461 · Free full text (PMC3743096)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	mTORC1
Model	Review
Effect	Reviews how mTORC1 integrates signals to coordinate nutrient input with biosynthetic output

In the Atlas

Cite this paper

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Dibble, C. C., & Manning, B. D. (2013). Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nature cell biology. https://doi.org/10.1038/ncb2763

@article{DIB2013,
  author       = {Dibble, C. C. and Manning, B. D.},
  title        = {{Signal integration by mTORC1 coordinates nutrient input with biosynthetic output}},
  journal      = {Nature cell biology},
  year         = {2013},
  doi          = {10.1038/ncb2763},
  note         = {PMID: 23728461},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record DIB2013) [Data set]. https://mtor-atlas.org/study/DIB2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DIB2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DIB2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DIB2013/},
  doi          = {10.5281/zenodo.22059963}
}

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