An ANGPTL8-AKT2-mTOR Axis Drives Adipose Senescence and Aging-Related Functional Decline

He Y, Pan L, Ping W et al. · 2026 · Aging Cell · Atlas ID HE2026

What this study shows

Identifies ANGPTL8 as an endocrine driver of adipose-tissue aging: circulating ANGPTL8 tracked with biological age and mortality risk in a large human cohort, and genetic deletion of Angptl8 in mice extended lifespan and reduced senescence markers. Mechanistically, ANGPTL8 binds AKT2 and drives the AKT-mTOR-S6K axis to promote adipocyte senescence; blocking that axis abolished the pro-senescent effect.

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Human cohort (correlation) + mouse (Angptl8-/- knockout, lifespan) + primary adipocyte/cell studies); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Human cohort (correlation) + mouse (Angptl8-/- knockout, lifespan) + primary adipocyte/cell studies
Journal	Aging Cell
Year	2026
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1111/acel.70671 · PMID 42605193

Cite this paper

ShowHide

He, Y., et al. (2026). An ANGPTL8-AKT2-mTOR Axis Drives Adipose Senescence and Aging-Related Functional Decline. Aging Cell. https://doi.org/10.1111/acel.70671

@article{HE2026,
  author       = {He, Y. and Pan, L. and Ping, W. and others},
  title        = {{An ANGPTL8-AKT2-mTOR Axis Drives Adipose Senescence and Aging-Related Functional Decline}},
  journal      = {Aging Cell},
  year         = {2026},
  doi          = {10.1111/acel.70671},
  note         = {PMID: 42605193},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record HE2026) [Data set]. https://mtor-atlas.org/study/HE2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_HE2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record HE2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/HE2026/},
  doi          = {10.5281/zenodo.22059963}
}