Oliver's mTOR Atlas Evidence Platform
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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

Yu Yonghao, Blenis J et al. · 2011 · Science · Atlas ID YUX2011

What this study shows

Phosphoproteomics identify Grb10 as an mTORC1 substrate driving negative feedback on insulin/PI3K.

Abstract

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The evolutionarily conserved serine-threonine kinase mammalian target of rapamycin (mTOR) plays a critical role in regulating many pathophysiological processes. Functional characterization of the mTOR signaling pathways, however, has been hampered by the paucity of known substrates. We used large-scale quantitative phosphoproteomics experiments to define the signaling networks downstream of mTORC1 and mTORC2.

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At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemMammalian cells
JournalScience
Year2011
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1126/science.1199484 · PMID 21659605 · Free full text (PMC3195509)

Extracted findings

InterventionPhosphoproteomics (mTORC1/Grb10)
TargetmTORC1 / Grb10 / insulin signaling
ModelMammalian cells
EffectGrb10 is an mTORC1 substrate that negatively feeds back on insulin/IGF signaling

In the Atlas

Related topics

Grb10

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Cite this paper

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Yu Yonghao, et al. (2011). Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science. https://doi.org/10.1126/science.1199484

@article{YUX2011,
  author       = {Yu Yonghao and Blenis, J. and others},
  title        = {{Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling}},
  journal      = {Science},
  year         = {2011},
  doi          = {10.1126/science.1199484},
  note         = {PMID: 21659605},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record YUX2011) [Data set]. https://mtor-atlas.org/study/YUX2011/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_YUX2011,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record YUX2011},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/YUX2011/},
  doi          = {10.5281/zenodo.22059963}
}