Yonghao Yu
Used phosphoproteomics to show that mTORC1 phosphorylates and stabilises Grb10, which then acts as a feedback brake on insulin and IGF-1 signalling
Professor, Columbia University Irving Medical Center · Associate Professor, UT Southwestern · postdoc, Harvard Medical School (Steven Gygi & John Blenis) · PhD Chemistry, UC Berkeley (Julie Leary) · BS Chemistry, Fudan Univ.
Yu Lab, Columbia University Irving Medical Center (New York, New York, USA) ↗ Lab lineagetrained under John Blenis → Bluesky@yu-yonghao.bsky.social ↗ ORCID0000-0002-7289-7748 ↗
Portrait: UT Southwestern Medical Center
As Blenis-lab postdoc, large-scale phosphoproteomics (YUX2011) identified Grb10 as a direct mTORC1 substrate whose stabilization suppresses PI3K/ERK-MAPK signaling downstream of insulin/IGF-1 receptor — discovered independently and near-simultaneously by Sabatini lab's Peggy Hsu (also in this Atlas).
Trained as a chemist before biology; built labs at UT Southwestern then Columbia, studying covalent protein modifications (phosphorylation, poly-ADP-ribosylation, tyrosine sulfation) and covalent drugs against 'undruggable' targets.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2011 | M | Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling YUX2011 Phosphoproteomics identify Grb10 as a direct mTORC1 substrate creating negative feedback on insulin/PI3K signaling. |
Co-authors in the Atlas 3
People with a profile here who share at least one study with Yonghao Yu.
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- John Blenis Showed early on that rapamycin blocks S6 kinase, then worked out how mTORC1 drives cell growth through its two main translation targets, S6K1 and 4E-BP1. His lab also found, in parallel with the Sabatini lab, that mTORC1 phosphorylates Grb10, a feedback brake on insulin signalling
- Lewis C. Cantley Co-discovered PI3K, the pathway that feeds into mTOR from growth factors
- Steven P. Gygi Mass-spectrometry scientist whose Harvard lab builds large-scale proteomics methods, including the BioPlex human protein-interaction map, and contributed proteomics to the discoveries of the CASTOR and SAMTOR nutrient sensors
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