A systematic screen of 564 yeast gene deletions found TOR and Sch9 pathway genes as the strongest lifespan-extending hits.
| Evidence tier | C Animal in vivo |
| Study type | 4 - Animal Study |
| Model system | Yeast (Saccharomyces cerevisiae) |
| Journal | Science |
| Year | 2005 |
| Peer reviewed | Yes |
| Source | DOI 10.1126/science.1115535 · PMID 16293764 |
Calorie restriction increases life span in many organisms, including the budding yeast Saccharomyces cerevisiae. From a large-scale analysis of 564 single-gene-deletion strains of yeast, we identified 10 gene deletions that increase replicative life span. Six of these correspond to genes encoding components of the nutrient-responsive TOR and Sch9 pathways. Calorie restriction of tor1D or sch9D cells failed to further increase life span and, like calorie restriction, deletion of either SCH9 or TOR1 increased life span independent of the Sir2 histone deacetylase. We propose that the TOR and Sch9 kinases define a primary conduit through which excess nutrient intake limits longevity in yeast.
| Intervention | Genetic (tor1Δ, sch9Δ) + caloric restriction |
| Target | TOR / Sch9 |
| Model | Yeast (S. cerevisiae) |
| Effect | Deleting TOR or Sch9 extends yeast replicative lifespan, overlapping with the caloric-restriction effect |