Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

Kaeberlein M, Powers RW, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK · 2005 · Science · Atlas ID KAE2005

What this study shows

A systematic screen of 564 yeast gene deletions found 10 deletions that extend replicative lifespan; genes of the nutrient-responsive TOR and Sch9 pathways were the most frequent hits (6 of 10).

Abstract

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Calorie restriction increases life span in many organisms, including the budding yeast Saccharomyces cerevisiae. From a large-scale analysis of 564 single-gene-deletion strains of yeast, we identified 10 gene deletions that increase replicative life span. Six of these correspond to genes encoding components of the nutrient-responsive TOR and Sch9 pathways. Calorie restriction of tor1D or sch9D cells failed to further increase life span and, like calorie restriction, deletion of either SCH9 or TOR1 increased life span independent of the Sir2 histone deacetylase.

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At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Yeast (Saccharomyces cerevisiae)) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Yeast (Saccharomyces cerevisiae)
Journal	Science
Year	2005
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1126/science.1115535 · PMID 16293764

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic (tor1Δ, sch9Δ) + caloric restriction
Target	TOR / Sch9
Model	Yeast (S. cerevisiae)
Effect	Deleting TOR or Sch9 extends yeast replicative lifespan, overlapping with the caloric-restriction effect

In the Atlas

Cite this paper

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Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005). Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science. https://doi.org/10.1126/science.1115535

@article{KAE2005,
  author       = {Kaeberlein, M. and Powers, R. W. and Steffen, K. K. and Westman, E. A. and Hu, D. and Dang, N. and Kerr, E. O. and Kirkland, K. T. and Fields, S. and Kennedy, B. K.},
  title        = {{Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients}},
  journal      = {Science},
  year         = {2005},
  doi          = {10.1126/science.1115535},
  note         = {PMID: 16293764},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record KAE2005) [Data set]. https://mtor-atlas.org/study/KAE2005/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_KAE2005,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record KAE2005},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/KAE2005/},
  doi          = {10.5281/zenodo.22059963}
}

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