A mammalian protein targeted by G1-arresting rapamycin-receptor complex

Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, Schreiber SL · 1994 · Nature · Atlas ID BRO1994

What this study shows

Purified FRAP (mTOR) as the mammalian FKBP12-rapamycin target homologous to yeast TOR1/2.

Abstract

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The structurally related natural products rapamycin and FK506 bind to the same intracellular receptor, FKBP12, yet the resulting complexes interfere with distinct signalling pathways. FKBP12-rapamycin inhibits progression through the G1 phase of the cell cycle in osteosarcoma, liver and T cells as well as in yeast, and interferes with mitogenic signalling pathways that are involved in G1 progression, namely with activation of the protein p70S6k (refs 5, 11-13) and cyclin-dependent kinases.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Bovine brain; in vitro) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Bovine brain; in vitro
Journal	Nature
Year	1994
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/369756a0 · PMID 8008069

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Biochemical (FKBP12-rapamycin complex)
Target	mTOR (FRAP) / FKBP12
Model	Bovine brain; in vitro
Effect	Identifies the mammalian FKBP12-rapamycin target protein that controls G1 cell-cycle progression

In the Atlas

Links in the pathway map

Cite this paper

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Brown, E. J., Albers, M. W., Shin, T. B., Ichikawa, K., Keith, C. T., Lane, W. S., & Schreiber, S. L. (1994). A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature. https://doi.org/10.1038/369756a0

@article{BRO1994,
  author       = {Brown, E. J. and Albers, M. W. and Shin, T. B. and Ichikawa, K. and Keith, C. T. and Lane, W. S. and Schreiber, S. L.},
  title        = {{A mammalian protein targeted by G1-arresting rapamycin-receptor complex}},
  journal      = {Nature},
  year         = {1994},
  doi          = {10.1038/369756a0},
  note         = {PMID: 8008069},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record BRO1994) [Data set]. https://mtor-atlas.org/study/BRO1994/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BRO1994,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BRO1994},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BRO1994/},
  doi          = {10.5281/zenodo.22059963}
}

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